Document Detail

Hiatal hernia predisposes to nocturnal gastro-oesophageal reflux.
MedLine Citation:
PMID:  24917956     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Nocturnal reflux has been associated with severe complications of gastro-oesophageal reflux disease and a poorer quality of life. Hiatal hernia predisposes to increased oesophageal acid exposure, but the effect on night reflux symptoms has never been investigated. The aim of the study was to investigate if hiatal hernia is associated with more frequent and severe night reflux symptoms.
METHODS: A total of 215 consecutive patients (110 male, mean age 52.6 ± 14.7 years) answered a detailed questionnaire on frequency and severity of specific day and night reflux symptoms. Subsequently, all patients underwent upper endoscopy and were categorized in two groups based on the endoscopic presence of hiatal hernia.
RESULTS: Patients with hiatal hernia were more likely to have nocturnal symptoms compared to those without hiatal hernia (78.6 vs. 51.8%, p = 0.0001); 59.2% of patients with hiatal hernia reported heartburn and 60.2% regurgitation compared to 43.8 and 39.3% of those without hiatal hernia, respectively (p = 0.033 and p = 0.003). The proportions of patients with day heartburn or regurgitation were not significantly different between the two groups. Night heartburn and regurgitation were graded as significantly more severe by patients with hiatal hernia (4.9 ± 4.2 vs. 3.2 ± 3.7, p = 0.002, and 3.8 ± 4.2 vs. 2.2 ± 3.5, p = 0.001, respectively). Patients with hiatal hernia had more frequent weekly night heartburn and regurgitation compared to those without hiatal hernia (p = 0.004 and p = 0.008, respectively).
CONCLUSIONS: More patients with hiatal hernia reported nocturnal reflux symptoms compared to those without hiatal hernia. Furthermore, nocturnal reflux symptoms were significantly more frequent and graded as significantly more severe in patients with presence of hiatal hernia rather than in those without hiatal hernia.
Georgios Karamanolis; Dimitrios Polymeros; Konstantinos Triantafyllou; Adam Adamopoulos; Charalampos Barbatzas; Irini Vafiadis; Spiros D Ladas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  United European gastroenterology journal     Volume:  1     ISSN:  2050-6406     ISO Abbreviation:  United European Gastroenterol J     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2014-06-11     Completed Date:  2014-06-11     Revised Date:  2014-06-13    
Medline Journal Info:
Nlm Unique ID:  101606807     Medline TA:  United European Gastroenterol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  -    
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