| Hexokinase isozyme pattern in CCl(4)-injured rat liver. | |
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MedLine Citation:
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PMID: 165018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activities of hexokinase isozymes in carbon tetrachloride (CCl(4))-injured rat liver were determined quantitatively by DEAE-cellulose column chromatography and compared with those of regenerating liver, fetal liver and ascites hepatoma cells (AH 130). The CCl(4)-injured liver revealed an isozyme distribution with predominant Types I, II and III (3.2, 8.8 and 6.8 times higher than the control values, respectively) and with undetectable activity of Type IV hexokinase (glucokinase). Although the isozyme pattern generally resembled that of fetal liver or hepatoma cells, the relatively high activity of hexokinase Type III in CCl(4) treatment characterizes the pattern of hexokinase isozyme in acue liver damage. |
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Authors:
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M Ueda; K Taketa; K Kosaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 60 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1975-07-24 Completed Date: 1975-07-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 77-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Tetrachloride Poisoning / enzymology* Carcinoma, Hepatocellular / enzymology Chromatography, DEAE-Cellulose Fasting Fetus Hexokinase / isolation & purification, metabolism* Isoenzymes / isolation & purification, metabolism* Kinetics Liver / enzymology* Liver Neoplasms Liver Regeneration Neoplasms, Experimental / enzymology Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 2.7.1.1/Hexokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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