Document Detail

Hexahydrophthalic acid in urine as an index of exposure to hexahydrophthalic anhydride.
MedLine Citation:
PMID:  1856027     Owner:  NLM     Status:  MEDLINE    
Post-shift and next-morning urine was sampled from workers exposed to hexahydrophtalic anhydride (HHPA), an epoxy hardener, sensitising at low exposure levels. Exposure levels of HHPA in air (gas chromatography, GC) in the range of 30-270 micrograms/m3 corresponded to urinary concentrations of 0.9-2.8 mumol hexahydrophthalic acid (HHP acid; GC-mass spectrometry)/mmol creatinine. In the morning samples the concentrations were less than 0.04-0.3 mumol HHP acid/mmol creatinine. In unexposed controls, the level was less than 0.1 mumol/mmol creatinine. A correlation was found between the time-weighted levels of HHPA in air and HHP acid in the post-shift urine (rs = 0.93; P less than 0.023), indicating that the determination of HHP acid in urine is suitable for biologic monitoring of HHPA exposure.
B Jönsson; H Welinder; G Skarping
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  63     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-23     Completed Date:  1991-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  77-9     Citation Subset:  IM    
Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.
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MeSH Terms
Air Pollutants, Occupational / analysis*
Creatinine / urine
Epoxy Resins / analysis*
Middle Aged
Monitoring, Physiologic
Occupational Exposure*
Phthalic Acids / urine*
Phthalic Anhydrides / analysis*
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Epoxy Resins; 0/Phthalic Acids; 0/Phthalic Anhydrides; 37226-48-5/araldite; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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