Document Detail

Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors.
MedLine Citation:
PMID:  9389666     Owner:  NLM     Status:  MEDLINE    
The divergent homeobox gene Hex exhibits three notable expression patterns during early mouse development. Initially Hex is expressed in the primitive endoderm of the implanting blastocyst but by 5.5 dpc its transcripts are present only in a small patch of visceral endoderm at the distal tip of the egg cylinder. Lineage analysis shows that these cells move unilaterally to assume an anterior position while continuing to express Hex. The primitive streak forms on the opposite side of the egg cylinder from this anterior Hex expression domain approximately 24 hours after the initial anterior movement of the distal visceral endoderm. Thus, Hex expression marks the earliest unequivocal molecular anteroposterior asymmetry in the mouse embryo and indicates that the anteroposterior axis of the embryo develops from conversion of a proximodistal asymmetry established in the primitive endoderm lineage. Subsequently, Hex is expressed in the earliest definitive endoderm to emerge from the streak and its expression within the gut strongly suggests that the ventral foregut is derived from the most anterior definitive endoderm and that the liver is probably the most anterior gut derivative. Hex is also an early marker of the thyroid primordium. Within the mesoderm, Hex is transiently expressed in the nascent blood islands of the visceral yolk sac and later in embryonic angioblasts and endocardium. Comparison with flk-1 (T. P. Yamaguchi et al., Development 118, 489-498, 1993) expression indicates that Hex is also an early marker of endothelial precursors but its expression in this progenitor population is much more transient than that of flk-1, being downregulated once endothelial cell differentiation commences.
P Q Thomas; A Brown; R S Beddington
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  125     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-12     Completed Date:  1998-02-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  85-94     Citation Subset:  IM    
MRC National Institute for Medical Research, London, UK.
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MeSH Terms
Body Patterning*
Carbocyanines / metabolism
Cell Differentiation
Digestive System / embryology
Embryo, Mammalian / metabolism*
Embryonic and Fetal Development
Endoderm / physiology
Endothelium, Vascular / cytology*,  embryology
Gastrula / physiology
Gene Expression Regulation, Developmental*
Genes, Homeobox / genetics*
Homeodomain Proteins / genetics*
In Situ Hybridization
Neovascularization, Physiologic
RNA, Messenger / analysis
Receptor Protein-Tyrosine Kinases / genetics
Receptors, Growth Factor / genetics
Receptors, Vascular Endothelial Growth Factor
Stem Cells / cytology
Transcription Factors
Reg. No./Substance:
0/3,3'-dihexadecylindocarbocyanine; 0/Carbocyanines; 0/Hhex protein, mouse; 0/Homeodomain Proteins; 0/RNA, Messenger; 0/Receptors, Growth Factor; 0/Transcription Factors; EC Protein-Tyrosine Kinases; EC, Vascular Endothelial Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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