| Heterotypic and homotypic re-inoculation of mice already latently infected with herpes simplex virus type 1. | |
| | |
MedLine Citation:
|
PMID: 2155598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mice were infected at 4 weeks of age with a type 1 strain of herpes simplex virus (HSV) and re-infected 4 weeks later with either a type 1 or a type 2 strain of HSV. The virus used for first infection could be distinguished from that used later since it was resistant to phosphonoformic acid and formed syncytial plaques. Sites used for the second inoculation were as follows: at the site of primary infection, at a different site within the same dermatome or in the equivalent dermatome on the opposite side (also called "remote" site). Re-infection caused no detectable reactivation of the latent PFA resistant virus. After re-infection with a homotypic virus replication of the re-infecting virus was limited to the inoculation site. However after heterotypic re-infection the type 2 strain was occasionally isolated from the ganglia. Previous infection with the PFA resistant type 1 strain clearly reduced the ability of the homotypic or heterotypic strains to establish a latent infection. However, in a few animals ganglia were found to be latently infected with virus from both the first and second inoculations. Analysis of the results suggests that resistance to the establishment of a second latent infection in a ganglion is determined by the general immunity of the animal rather than "immunity" of the latently infected ganglion itself. |
| | |
Authors:
|
D L Yirrell; W A Blyth; T J Hill; C E Rogers |
Related Documents
:
|
9618568 - Social stress and the reactivation of latent herpes simplex virus type 1. 2550578 - A herpes simplex virus type 1 mutant containing a deletion within immediate early gene ... 15885838 - Borna disease virus interference with neuronal plasticity. 11197148 - Shedding of herpes simplex virus type 1 into tears and saliva in healthy japanese adults. 16960778 - Repeated intravaginal inoculation with cell-associated simian immunodeficiency virus re... 12427338 - Helminth and arthropod parasites of the brown pelican, pelecanus occidentalis, in puert... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Archives of virology Volume: 110 ISSN: 0304-8608 ISO Abbreviation: Arch. Virol. Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-04-06 Completed Date: 1990-04-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7506870 Medline TA: Arch Virol Country: AUSTRIA |
Other Details:
|
Languages: eng Pagination: 25-36 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, School of Medical Sciences University of Bristol, England. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antiviral Agents / antagonists & inhibitors Drug Resistance, Microbial Female Foscarnet Herpes Simplex / microbiology* Mice Mice, Inbred Strains Mutation Phosphonoacetic Acid / analogs & derivatives, antagonists & inhibitors Simplexvirus / drug effects, isolation & purification, pathogenicity* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 4408-78-0/Phosphonoacetic Acid; 4428-95-9/Foscarnet |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation of HHV-6-related virus from children affected by infectious syndrome.
Next Document: Gene mapping of infectious bovine rhinotracheitis viral DNA genome.