Document Detail

Heterotransplantation of experimentally induced sheep lung adenomatosis into nude mice.
MedLine Citation:
PMID:  6324309     Owner:  NLM     Status:  MEDLINE    
Male ICR nude mice inoculated subcutaneously with minced tissue obtained from pulmonary adenomatosis of sheep which was induced by RNA type-C retrovirus developed a transplant which contained cysts lined by a proliferative epithelium. These cysts showed several characteristics of the epithelial tumour cells of origin, such as high glycogen content and secretion of mucin. Microinvasion of epithelial cells from the adenomatous cysts into the stroma was observed. The stromal tissue demonstrated islets of cartilage. It was concluded that virus-induced pulmonary carcinoma of sheep can be transplanted and grown in nude mice.
A Zimber; K Perk; I Hod; S Irving; Y Yegana
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Research in veterinary science     Volume:  36     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-05-17     Completed Date:  1984-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  122-4     Citation Subset:  IM    
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MeSH Terms
Mice, Nude
Neoplasm Transplantation*
Pulmonary Adenomatosis, Ovine / etiology,  pathology*
Retroviridae / pathogenicity
Transplantation, Heterologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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