| Heterotopic pruritic conditioning and itch--analogous to DNIC in pain? | |
| | |
MedLine Citation:
|
PMID: 20226590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pain can be endogenously modulated by heterotopic noxious conditioning stimulation (HNCS) through a mechanism which is known as diffuse noxious inhibitory control (DNIC). Since DNIC can be impaired in patients suffering from chronic pain, a comparable impaired itch inhibition may exist in patients suffering from chronic itch. The aim of the present study was to investigate whether heterotopic pruritic conditioning stimulation (HPCS) would display an impaired modulation of itch in patients suffering from chronic itch compared with healthy subjects. To this end, electrical stimuli were applied before and after histamine application (HPCS) to female patients with psoriasis and healthy female control subjects. Subjects reported the intensity of electrically evoked itch before and after HPCS. In order to replicate earlier findings for DNIC, electrically evoked pain was additionally investigated before and after cold stimulation (HNCS). As expected, the intensity of itch evoked by the electrical stimulus was significantly less after than before HPCS in healthy subjects, and the same was found for the intensity of electrically evoked pain after compared to before HNCS. Contrarily, in the patients levels of electrically evoked itch were significantly higher after than before HPCS, and no significant difference in pain intensity before and after HNCS was observed. In line with pain modulation, results suggest that there is a DNIC analogous mechanism for itch, i.e., diffuse pruritic inhibitory control (DPIC), which is impaired in patients with chronic itch, possibly due to a dysregulation of descending itch modulatory systems. |
| | |
Authors:
|
Antoinette I M van Laarhoven; Floris W Kraaimaat; Oliver H Wilder-Smith; Peter C M van de Kerkhof; Andrea W M Evers |
Publication Detail:
|
Type: Journal Article Date: 2010-03-11 |
Journal Detail:
|
Title: Pain Volume: 149 ISSN: 1872-6623 ISO Abbreviation: Pain Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-27 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7508686 Medline TA: Pain Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 332-7 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. A.vanLaarhoven@mps.umcn.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Central Nervous System / physiopathology Chronic Disease Conditioning (Psychology) / drug effects, physiology* Electric Stimulation / adverse effects Female Histamine / pharmacology Histamine Agonists / pharmacology Humans Middle Aged Neural Inhibition / drug effects, physiology* Neural Pathways / physiopathology Nociceptors / drug effects, physiology* Pain / physiopathology Pruritus / chemically induced, physiopathology* Psoriasis / physiopathology Sensory Receptor Cells / drug effects, physiology* Skin / innervation, physiopathology* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Histamine Agonists; 51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Some biomedical applications of Balanites aegyptiaca grown naturally in radioactive area, Southeaste...
Next Document: Molecular recognition imaging using tuning fork-based transverse dynamic force microscopy.