Document Detail

Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the etiology and pathophysiology.
MedLine Citation:
PMID:  23196266     Owner:  NLM     Status:  In-Data-Review    
Neurogenic heterotopic ossification (HO) is the ectopic formation of lamellar bone in non-osseous tissues following traumatic brain or spinal cord injury. The associated complications affect greatly their quality of life. This fact has shifted the focus of scientific effort towards the investigation and understanding of related risk factors and the pathophysiological mechanisms. Recent advancements include the investigation for genetic predisposition and association various biomarkers. In the present article we will analyze the current concepts on this topic, based on clinical and physiological evidence and we will discuss the potential areas for future research on this field.
V I Sakellariou; E Grigoriou; A F Mavrogenis; P N Soucacos; P J Papagelopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of musculoskeletal & neuronal interactions     Volume:  12     ISSN:  1108-7161     ISO Abbreviation:  J Musculoskelet Neuronal Interact     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101084496     Medline TA:  J Musculoskelet Neuronal Interact     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  230-40     Citation Subset:  IM    
First Department of Orthopaedic Surgery, Athens University Medical School, Athens, Greece.
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