Document Detail

Heterotopic ossification after total hip arthroplasty (THA) in congenital hip disease: comparison of two different prophylactic protocols.
MedLine Citation:
PMID:  19211376     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: We aimed to evaluate retrospectively the efficacy of combined postoperative radiotherapy and indomethacin compared to indomethacin alone for the prevention of heterotopic ossification (HO) in high-risk patients with congenital disease of hip (CDH) undergoing total hip arthroplasty (THA). MATERIALS AND METHODS: Fifty-five patients received indomethacin alone (Group A), while 44 patients received the combined protocol (Group B). Patients >or=55 years were enrolled in Group B and those younger than 55 years in Group A. Patients were evaluated radiologically for the presence of HO 6 months after the operation. RESULTS: The incidence of HO in Group A was 34.5% (95% confidence interval 22.2-48.6%), while the respective incidence in Group B patients was 27.3% (95% CI 15.0- 42.8%). The difference was not statistically significant (p=0.5). No significant treatment-related side effects were reported. CONCLUSIONS: This is the first study evaluating the impact of HO prophylaxis in an immiscible population of patients with secondary arthritis due to CDH undergoing THA. Further future randomised evidence is required in order to ascertain the observed trend towards improved efficacy of the combined protocol for HO development.
E E Pakos; K S Stafilas; A N Politis; P G Tsekeris; G Mitsionis; T A Xenakis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico     Volume:  11     ISSN:  1699-048X     ISO Abbreviation:  -     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-06-18     Revised Date:  2009-08-02    
Medline Journal Info:
Nlm Unique ID:  101247119     Medline TA:  Clin Transl Oncol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
Department of Orthopaedic Surgery, University Hospital of Ioannina, University of Ioannina, School of Medicine, Ioannina, Greece.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Arthroplasty, Replacement, Hip*
Combined Modality Therapy
Hip Dislocation, Congenital / complications,  surgery*
Indomethacin* / therapeutic use
Middle Aged
Ossification, Heterotopic* / etiology,  prevention & control
Postoperative Period
Preoperative Care
Range of Motion, Articular
Retrospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin

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