Document Detail


Heterotopic neogenesis of skeletal muscle induced in the adult rat diaphragmatic peritoneum: ultrastructural and transplantation studies.
MedLine Citation:
PMID:  10506929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the course of a mild chemical peritonitis, new skeletal muscle fibers develop and persist over a twelve-month interval in the diaphragmatic peritoneum. Light and electron microscopic studies revealed that the ectopic fibers developed from myoblasts and myotubes to fully differentiated muscle cells in the same manner as normally situated skeletal muscle. The ectopic fibers were separated from the intrinsic muscle by dense connective tissue and an elastic lamina. Diaphragms taken from normal rats and transplanted to the omentum of isogeneic recipients also developed skeletal muscle neogenesis in the same ectopic location as in the normal diaphragm. Satellite cells, reactive fibroblasts in the peritoneum, mesenchymal stem cells or blood-borne myoblast precursor cells could be the source of these ectopic muscle fibers. The results of the present studies, however, cannot provide conclusive evidence for the origin of the new muscle fibers. Regardless of their source, the methods employed may represent a unique model for the development and prolonged maintenance of skeletal muscle fibers in a heterotopic location in vivo.
Authors:
A B Drakontides; M J Danon; S Levine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  14     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-26     Completed Date:  1999-11-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  1135-43     Citation Subset:  IM    
Affiliation:
Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595, USA. anna_drakontides@nymc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Diaphragm / immunology,  transplantation,  ultrastructure
Humans
Muscle, Skeletal / transplantation,  ultrastructure*
Peritoneum / immunology,  ultrastructure*
Peritonitis / chemically induced,  immunology,  pathology*
Rats
Rats, Inbred Lew
Tissue Transplantation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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