Document Detail

Heterotopic heart transplantation and recipient heart operation in ischemic heart disease.
MedLine Citation:
PMID:  1637229     Owner:  NLM     Status:  MEDLINE    
The role of heterotopic heart transplantation in coronary heart disease has not been defined. Between 1983 and 1988, 28 patients with end-stage ischemic heart disease were managed by heterotopic heart transplantation and adjunctive operation on the recipient heart: coronary artery bypass grafts and aneurysmectomy, 20; coronary artery bypass grafts, 5; and aneurysmectomy, 3. Indications were feasibility of operative procedures to the recipient heart and small donor size (61% of the donors were less than 15 years). The 1-year and 5-year actuarial survival was 79% and 63%. Of the 22 patients who survived to 2-year follow-up, all of whom had been severely limited (New York Heart Association grade III/IV) preoperatively, 20 were in grades I or II at 2-year follow-up (p less than 0.001). In 14 of 22 patients (64%), the recipient heart augmented the donor cardiac output substantially, and in 4 the recipient heart supported the patient when the donor heart failed to eject. In conclusion, this series demonstrates the efficacy of heterotopic transplantation combined with operation to the recipient heart in the management of patients with end-stage ischemic heart disease.
P D Ridley; A Khaghani; F Musumeci; R Favaloro; E S Akl; N R Banner; A G Mitchell; M H Yacoub
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  54     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-24     Completed Date:  1992-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-7     Citation Subset:  AIM; IM    
Department of Cardiothoracic Surgery, Harefield Hospital, Middlesex, England.
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MeSH Terms
Blood Pressure
Coronary Artery Bypass
Coronary Disease / mortality,  physiopathology,  surgery*
Heart / physiopathology
Heart Aneurysm / surgery
Heart Transplantation* / methods,  mortality
Middle Aged
Postoperative Complications
Pulmonary Artery / physiopathology
Tissue Donors
Transplantation, Heterotopic* / methods,  mortality
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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