Document Detail

Heterotopic Ossification Associated With rhBMP-2 (Infuse) in Posterolateral Lumbar Spine Fusion: A Case Report.
MedLine Citation:
PMID:  22020605     Owner:  NLM     Status:  Publisher    
Study Design. A case of heterotopic ossification in the lumbar spine associated with the off label use of rhBMP-2 is reported.Objective. To highlight a previously unreported complication of rhBMP-2 use and to review literature pertinent to the topic.Summary of Background Data. There is no report in the literature regarding a large mass of rhBMP-2 associated heterotopic ossification surrounding the paraspinal musculature.Methods. The clinical and radiographic features of this complication and treatment course are presented.Results. The surgical excision of heterotopic ossification and removal of symptomatic instrumuntation has resulted in the patient remaining asymptomatic at 1 year of follow up examination.Conclusion. The reported case adds to the literature of off label use of rhBMP-2 and the potential for the formation of heterotopic ossification with its use.
Christopher L Anderson; M Camden Whitaker
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-20
Journal Detail:
Title:  Spine     Volume:  -     ISSN:  1528-1159     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Surgery, Section of Orthopaedics, The University of Kansas School of Medicine - Wichita, 929 N. St. Francis, Wichita, KS.
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