Document Detail

Heterologous reactivity of in vitro cultured mouse cells with natural human serum antibodies.
MedLine Citation:
PMID:  327972     Owner:  NLM     Status:  MEDLINE    
Studies employing the cytotoxic and immunofluorescence tests revealed presence of natural human serum antibodies in the serum of various human donors, which reacted with normal and pathologic mouse cells cultivated in vitro. This reactivity was due to presence on the cell surface of heterologous HMAg antigen incorporated into the cell membrane from calf serum. Immunofluorescence studies demonstrated localization of this antigen on the cell surface. Absorption of human sera with calf serum or with lyophilized cow's milk abolished or markedly weakened the ability of these sera to react with cultured mouse cells.
R Richter; M Becker; A Harlozińska; B Golubska
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  25     ISSN:  0004-069X     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:  1977  
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
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MeSH Terms
Antibody Specificity
Antigens / analysis*
Cell Line
Cell Membrane / immunology
Cells, Cultured / immunology*
Culture Media
Cytotoxicity Tests, Immunologic
Fluorescent Antibody Technique
Leukemia / immunology
Neoplasms / immunology
Species Specificity
Reg. No./Substance:
0/Antibodies; 0/Antigens; 0/Culture Media

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