Document Detail


Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli.
MedLine Citation:
PMID:  23034674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the heterologous production of Ala(0)actagardine in E. coli by co-expression of the substrate peptide GarA and its modification enzymes GarM and GarO. The activity of GarO, a luciferase-like monooxygenase that introduces the unique sulfoxide group of actagardine, was also investigated in vitro.
Authors:
Yanxiang Shi; Alejandro Bueno; Wilfred A van der Donk
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  48     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-03-17     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  10966-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Bacteriocins / biosynthesis*
Escherichia coli* / metabolism
Molecular Sequence Data
Peptides
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Grant Support
ID/Acronym/Agency:
GM58822/GM/NIGMS NIH HHS; R01 GM058822/GM/NIGMS NIH HHS; S10 RR027109/RR/NCRR NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Bacteriocins; 0/Peptides; 59165-34-3/gardimycin
Comments/Corrections

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