| Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli. | |
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MedLine Citation:
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PMID: 23034674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the heterologous production of Ala(0)actagardine in E. coli by co-expression of the substrate peptide GarA and its modification enzymes GarM and GarO. The activity of GarO, a luciferase-like monooxygenase that introduces the unique sulfoxide group of actagardine, was also investigated in vitro. |
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Authors:
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Yanxiang Shi; Alejandro Bueno; Wilfred A van der Donk |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 48 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-15 Completed Date: 2013-03-17 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 10966-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S Mathews Ave, Urbana, IL 61801, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Bacteriocins / biosynthesis* Escherichia coli* / metabolism Molecular Sequence Data Peptides Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Grant Support | |
ID/Acronym/Agency:
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GM58822/GM/NIGMS NIH HHS; R01 GM058822/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Bacteriocins; 0/Peptides; 59165-34-3/gardimycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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