Document Detail

Heterogeneous tissue in the thyroid fossa on ultrasound in infants with proven thyroid ectopia on isotope scan--a diagnostic trap.
MedLine Citation:
PMID:  20066409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thyroid imaging is of proven help in establishing a diagnosis of congenital hypothyroidism in infants. US often shows tissue in the thyroid fossa when radionuclide scintigraphy reveals only ectopic uptake. OBJECTIVE: Our hypothesis was that the use of US alone could lead to the mistaken diagnosis of normal or dysplastic thyroid in cases of scintigraphy-proven thyroid ectopia. MATERIALS AND METHODS: We undertook a detailed retrospective review and analysis of imaging and concurrent biochemistry in infants with thyroid ectopia, confirmed by radionuclide scintigraphy. RESULTS: Eighteen infants had thyroid ectopia; ten of the original US reports had suggested that cervical thyroid tissue was present. Review showed bilateral tissue in the thyroid fossa in all that was non-thyroidal in nature since, apart from showing no radionuclide uptake, it exhibited some or all of the following typical features: hyperechogenicity, heterogeneity, small size, poor vascularity, and anechoic and/or hypoechoic cysts. Also, extension of the tissue both around and behind the large cervical blood vessels was a universal finding. CONCLUSION: Considerable experience is required to interpret neonatal thyroid US. We caution against diagnosing a dysplastic/hypoplastic thyroid gland in situ on the basis of US alone, particularly if the tissue exhibits any of the non-thyroidal features described.
Jeremy H Jones; Morag Attaie; Sanjay Maroo; David Neumann; Rebecca Perry; Malcolm D C Donaldson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-12
Journal Detail:
Title:  Pediatric radiology     Volume:  40     ISSN:  1432-1998     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  725-31     Citation Subset:  IM    
Department of Child Health, Royal Hospital for Sick Children, Dalnair Street, Yorkhill, Glasgow, Lanarkshire, G3 8SJ, UK.
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MeSH Terms
Choristoma / radionuclide imaging*,  ultrasonography*
Diagnostic Errors / prevention & control*
Infant, Newborn
Reproducibility of Results
Sensitivity and Specificity
Thyroid Gland / radionuclide imaging*,  ultrasonography*
Tongue Diseases / radionuclide imaging*,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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