| Heterogeneous seizure manifestations in Hypomelanosis of Ito: report of four new cases and review of the literature. | |
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MedLine Citation:
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PMID: 19902142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypomelanosis of Ito (HI) is a rare neuroectodermal disorder often associated with mental retardation and epilepsy. We report on four new HI patients presenting with heterogeneous seizure manifestations and we review the literature concerning epileptic seizures in HI. At one extreme, there are patients with generalized seizures well controlled by drug treatment, whereas at the opposite there are patients with severe, often pharmacoresistant, focal seizures. The genetic substrate for HI syndrome is not homogenous and only partially understood. Further researches are required to shed light on the pathogenesis of HI phenotypes. |
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Authors:
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Komi Assogba; Edoardo Ferlazzo; Pasquale Striano; Tiziana Calarese; Nathalie Villeneuve; Ivan Ivanov; Placido Bramanti; Edoardo Sessa; Iliana Pacheva; Pierre Genton |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-11-10 |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 31 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-26 Completed Date: 2010-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 9-16 Citation Subset: IM |
Affiliation:
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Centre Saint-Paul, H?pital Henri Gastaut, Marseille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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physiopathology,
radiography Child Electroencephalography Female Humans Hypopigmentation* / drug therapy, physiopathology, radiography Retrospective Studies Seizures* / drug therapy, physiopathology, radiography Tomography, X-Ray Computed Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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