Document Detail

Heterogeneous micromechanical properties of the extracellular matrix in healthy and infarcted hearts.
MedLine Citation:
PMID:  24717359     Owner:  NLM     Status:  Publisher    
Infarcted hearts are macroscopically stiffer than healthy organs. Nevertheless, although cell behavior is mediated by the physical features of the cell niche, intrinsic micromechanical properties of healthy and infarcted heart extracellular matrix (ECM) remain poorly characterized. We studied ECM micromechanics of different histological regions of the left ventricle wall of healthy and infarcted mice with atomic force microscopy. Hearts excised from healthy (N=8) and infarcted mice (N=8) were decellularized with sodium dodecyl sulphate and cut into 12 μm thick slices. Healthy ventricular ECM revealed marked mechanical heterogeneity across histological regions of the ventricular wall with the effective Young's modulus ranging from 30.2 ± 2.8 kPa to 74.5 ± 8.7 kPa in collagen and elastin rich regions of the myocardium, respectively. Infarcted ECM showed a predominant collagen composition and was 3-fold stiffer than collagen rich regions of the healthy myocardium. ECM of both healthy and infarcted hearts exhibited a solid-like viscoelastic behavior that conforms to two power law rheology. Knowledge of intrinsic micromechanical properties of the ECM at the length scale in which cells sense their environment will provide further insight into the cell-scaffold interplay in healthy and infarcted hearts.
Ion Andreu; Tomás Luque; Ana Sancho; Beatriz Pelacho; Olalla Iglesias; Esther Melo; Ramon Farré; Felipe Prósper; M Reyes Elizalde; Daniel Navajas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-6
Journal Detail:
Title:  Acta biomaterialia     Volume:  -     ISSN:  1878-7568     ISO Abbreviation:  Acta Biomater     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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