Document Detail

Heterogeneous medically unexplained symptoms and immune function.
MedLine Citation:
PMID:  17553664     Owner:  NLM     Status:  MEDLINE    
It has been suggested that dysregulation of immune-to-brain communication plays a role in the biopsychological process underlying medically unexplained symptoms (MUS). Immune and non-immune stressors can both be involved in the activation of the central sickness-behavioural-system leading to complaints like malaise, pain and fatigue. We hypothesized increased pro-inflammatory and/or reduced anti-inflammatory cytokine activity to exist in MUS patients. Twenty-seven participants (4 male; 23 female) with heterogeneous MUS were compared with 27 healthy controls (6 male; 21 females). Blood samples were analysed for leukocyte subset cell counts, in vitro T-cell mitogen-stimulated cytokine production (IL-2, IL-4, IL-5, IL-6, IL-10, TNF-alpha and IFN-gamma) and in vitro monocyte cytokine release (IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha) in response to increasing concentrations of LPS. No significant group differences were found for any of the cytokines measured. One unexpected exception was an elevation in the number of circulating B and NK-cells in participants high on MUS. Nonetheless, no support was found for the hypothesized immunological dysregulation in peripheral blood leukocyte function of MUS patients.
Jan H Houtveen; Annemieke Kavelaars; Cobi J Heijnen; Lorenz J P van Doornen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-05
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  21     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-04     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1075-82     Citation Subset:  IM    
Department of Clinical and Health Psychology, Utrecht University, Faculty of Social and Behavioural Sciences, P.O. Box 80.140, 3508 TC Utrecht, The Netherlands.
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MeSH Terms
Analysis of Variance
B-Lymphocytes / immunology
Case-Control Studies
Cytokines / blood*
Killer Cells, Natural / immunology
Lymphocyte Subsets / cytology,  immunology*
Middle Aged
Neuroimmunomodulation / immunology*
Reference Values
Sick Role*
Somatoform Disorders / blood,  immunology*
Statistics, Nonparametric
T-Lymphocytes / immunology
Reg. No./Substance:

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