Document Detail

Heterogeneous expression of connexin 43 in the myocardium of rabbit right ventricular outflow tract.
MedLine Citation:
PMID:  15848218     Owner:  NLM     Status:  MEDLINE    
The right ventricular outflow tract (RVOT) has been demonstrated as an important focus in idiopathic ventricular arrhythmias. However, the role of the gap junction in this region in arrhythmic events has not been fully investigated. The purpose of this study was to evaluate the expression and distribution of the gap junction protein connexin 43 (Cx43) in the myocardium of the RVOT area of normal adult rabbits. Tissue samples were obtained from 6 regions of normal rabbit heart, i.e. the left ventricle (LV) free wall, the LV papillary muscle, the RVOT free wall, and the RVOT septum which was subdivided into the RV side, the central layer, and the LV side. Immunohistochemical analysis was performed to investigate the characteristics of Cx43 distribution in the RVOT area. In the LV free wall and papillary muscle, Cx43 was abundantly, homogeneously, and approximately equally expressed in end-to-end- and side-to-side intercellular connections. In the free wall of the RVOT, Cx43 expression was poor compared to both these LV regions and side-to-side cell connections were predominant. Cx43 was as richly and homogeneously distributed in the central layer and LV side of the RVOT septum as in the two LV regions. However, in the RV side of the RVOT septum, its distribution was scant and an unstained area was noted. The heterogeneous expression of Cx43 in the RVOT area may serve as substrate for idiopathic ventricular arrhythmia.
Baiqing Ou; Mikiko Nakagawa; Munetaka Kajimoto; Seiki Nobe; Tatsuhiko Ooie; Masashi Ichinose; Hidetoshi Yonemochi; Noriaki Ono; Tatsuo Shimada; Tetsunori Saikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  77     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-06-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  52-9     Citation Subset:  IM    
Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Oita 879-5593, Japan.
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MeSH Terms
Connexin 43 / analysis,  metabolism*
Digoxin / pharmacology
Gap Junctions / physiology*
Heart Ventricles / drug effects,  metabolism*
Myocardium / immunology,  metabolism
Tachycardia, Ventricular / metabolism*
Ventricular Function
Ventricular Function, Right / physiology*
Reg. No./Substance:
0/Connexin 43; 20830-75-5/Digoxin

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