| Heterogeneous expression of blood group A-determinant in a human gastric cancer cell line derived from a blood group A individual. | |
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MedLine Citation:
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PMID: 1373646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human gastric cancer cell line MKN 45 was derived from the tumour of a blood group A individual, and was known to express large quantities of blood group A-antigen. Using immunofluorescence we found the MKN 45 cells, donated from the Japanese Cancer Research Resources Bank, consisted of A-antigen positive cells (18%) and A-antigen negative cells (82%). After limiting dilution, wild type and mutant cells were cloned with regard to the expression of a cell surface A-antigen. ELISA was used to detect A-antigen in the cell extract of the wild type cells, but none was evident in those of the mutant cells. However, blood group A-gene-specified transferase activity of the mutant cells was comparable to that of the wild type cells. |
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Authors:
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Y Kominato; T Fujikura; H Takizawa; K Hayashi; M Fujimaki; K Kishi; T Suzuki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics Volume: 19 ISSN: 0960-7420 ISO Abbreviation: Eur. J. Immunogenet. Publication Date: 1992 Feb-Apr |
Date Detail:
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Created Date: 1992-05-27 Completed Date: 1992-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9106962 Medline TA: Eur J Immunogenet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Department of Legal Medicine, Toyama Medical & Pharmaceutical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System
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biosynthesis*,
genetics Epitopes / biosynthesis, genetics Fluorescent Antibody Technique Gene Expression Glycosyltransferases / genetics Humans Polymorphism, Genetic Stomach Neoplasms / genetics, immunology* Tumor Cells, Cultured / enzymology, immunology |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System; 0/Epitopes; EC 2.4.-/Glycosyltransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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