| Heterogeneous distribution of the unusual phospholipid semilysobisphosphatidic acid through the Golgi complex. | |
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MedLine Citation:
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PMID: 9362065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the distribution of lipids through the Golgi complex, we analyzed the envelopes of several viruses that assemble in different subcompartments of the Golgi, as well as subcellular fractions. Our results indicate that each Golgi subcompartment has a distinct phospholipid composition due mainly to differences in the relative amounts of semilysobisphosphatidic acid (SLBPA), sphingomyelin, phosphatidylserine, and phosphatidylinositol. Interestingly, SLBPA is enriched in the adjacent Golgi networks compared with the Golgi stack, and this enrichment varies with cell type. The heterogeneous distribution of SLBPA through the Golgi complex suggests it may play an important role in the structure and/or function of this organelle. |
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Authors:
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E B Cluett; E Kuismanen; C E Machamer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular biology of the cell Volume: 8 ISSN: 1059-1524 ISO Abbreviation: Mol. Biol. Cell Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1997-12-11 Completed Date: 1997-12-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9201390 Medline TA: Mol Biol Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2233-40 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2105, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Extracts Cell Fractionation Cell Line Cricetinae Dogs Golgi Apparatus / chemistry*, virology Kidney Phosphatidic Acids / analysis* Phospholipids / analysis RNA Viruses / metabolism Receptor, IGF Type 2 / analysis Virus Assembly |
| Grant Support | |
ID/Acronym/Agency:
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P01 DK-44375/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Extracts; 0/Phosphatidic Acids; 0/Phospholipids; 0/Receptor, IGF Type 2; 0/semilysobisphosphatidic acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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