Document Detail

Heterogeneous distribution of the unusual phospholipid semilysobisphosphatidic acid through the Golgi complex.
MedLine Citation:
PMID:  9362065     Owner:  NLM     Status:  MEDLINE    
To investigate the distribution of lipids through the Golgi complex, we analyzed the envelopes of several viruses that assemble in different subcompartments of the Golgi, as well as subcellular fractions. Our results indicate that each Golgi subcompartment has a distinct phospholipid composition due mainly to differences in the relative amounts of semilysobisphosphatidic acid (SLBPA), sphingomyelin, phosphatidylserine, and phosphatidylinositol. Interestingly, SLBPA is enriched in the adjacent Golgi networks compared with the Golgi stack, and this enrichment varies with cell type. The heterogeneous distribution of SLBPA through the Golgi complex suggests it may play an important role in the structure and/or function of this organelle.
E B Cluett; E Kuismanen; C E Machamer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular biology of the cell     Volume:  8     ISSN:  1059-1524     ISO Abbreviation:  Mol. Biol. Cell     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-11     Completed Date:  1997-12-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9201390     Medline TA:  Mol Biol Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2233-40     Citation Subset:  IM    
Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2105, USA.
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MeSH Terms
Cell Extracts
Cell Fractionation
Cell Line
Golgi Apparatus / chemistry*,  virology
Phosphatidic Acids / analysis*
Phospholipids / analysis
RNA Viruses / metabolism
Receptor, IGF Type 2 / analysis
Virus Assembly
Grant Support
Reg. No./Substance:
0/Cell Extracts; 0/Phosphatidic Acids; 0/Phospholipids; 0/Receptor, IGF Type 2; 0/semilysobisphosphatidic acid

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