| Heterogeneous distribution of myocardial steatosis--an ex vivo evaluation. | |
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MedLine Citation:
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PMID: 22576623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial fat accumulation could occur in diseased hearts. The degree of heterogeneity is unknown because accurate assessment is difficult using conventional proton magnetic resonance spectroscopy techniques in a beating heart. The purpose of this study was to characterize the distribution of intramyocellular lipid content and to determine its association with disease characteristics. Proton magnetic resonance spectroscopy was performed on formalin-fixed slices of human hearts at various circumferential locations (N = 55). Twenty-nine percent of the hearts had the highest fat content measured in the septum, followed by posterior (27%), lateral (26%), and anterior (18%) wall. Age was significantly correlated with the mean fat percentages (r2 = 0.12, P = 0.007). Those who died from cardiovascular disease demonstrated significantly higher and more heterogeneous fat distribution than those who did not (1.62% ± 1.1% vs. 0.59% ± 0.4%, P = 0.002). In summary, septal fat content is representative of mean fat percentage. Fat content increases with age; fat distribution may be heterogeneous when associated with cardiovascular disease. |
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Authors:
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Chia-Ying Liu; Yuan Chang Liu; Bharath Ambale Venkatesh; Joao A C Lima; David A Bluemke; Charles Steenbergen |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural Date: 2012-05-10 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 68 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-13 Completed Date: 2012-11-07 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA. Cliu51@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity* Aging / metabolism* Cardiomyopathies / metabolism* Female Humans Lipid Metabolism* Lipid Metabolism Disorders / metabolism* Magnetic Resonance Spectroscopy / methods* Male Middle Aged Protons / diagnostic use Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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R21HL098827/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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