Document Detail


Heterogeneous distribution of myocardial steatosis--an ex vivo evaluation.
MedLine Citation:
PMID:  22576623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial fat accumulation could occur in diseased hearts. The degree of heterogeneity is unknown because accurate assessment is difficult using conventional proton magnetic resonance spectroscopy techniques in a beating heart. The purpose of this study was to characterize the distribution of intramyocellular lipid content and to determine its association with disease characteristics. Proton magnetic resonance spectroscopy was performed on formalin-fixed slices of human hearts at various circumferential locations (N = 55). Twenty-nine percent of the hearts had the highest fat content measured in the septum, followed by posterior (27%), lateral (26%), and anterior (18%) wall. Age was significantly correlated with the mean fat percentages (r2 = 0.12, P = 0.007). Those who died from cardiovascular disease demonstrated significantly higher and more heterogeneous fat distribution than those who did not (1.62% ± 1.1% vs. 0.59% ± 0.4%, P = 0.002). In summary, septal fat content is representative of mean fat percentage. Fat content increases with age; fat distribution may be heterogeneous when associated with cardiovascular disease.
Authors:
Chia-Ying Liu; Yuan Chang Liu; Bharath Ambale Venkatesh; Joao A C Lima; David A Bluemke; Charles Steenbergen
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-10
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  68     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-13     Completed Date:  2012-11-07     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adiposity*
Aging / metabolism*
Cardiomyopathies / metabolism*
Female
Humans
Lipid Metabolism*
Lipid Metabolism Disorders / metabolism*
Magnetic Resonance Spectroscopy / methods*
Male
Middle Aged
Protons / diagnostic use
Tissue Distribution
Grant Support
ID/Acronym/Agency:
R01 HL039752/HL/NHLBI NIH HHS; R21 HL098827/HL/NHLBI NIH HHS; R21HL098827/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Protons
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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