Document Detail

Heterogeneous distribution of functionally important amino acids in brain areas of adult and aging humans.
MedLine Citation:
PMID:  8474566     Owner:  NLM     Status:  MEDLINE    
The regional distribution of seven amino acids thought to have inhibitory neurotransmitter or neurotransmitter precursor function--GABA, glycine, taurine, serine, threonine, phenylalanine, and tyrosine--was determined in 52 discrete areas from brain of adult and old humans. Significant heterogeneity was found, with 3- to 16-fold differences in levels in the various regions analyzed. The patterns of distribution were somewhat different from those in the adult or old rat brain. Relatively few changes were seen in old brain. Heterogeneity in distribution has to be taken into account in assessing physiological changes in amino acid levels and metabolism.
M Banay-Schwartz; M Palkovits; A Lajtha
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurochemical research     Volume:  18     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-19     Completed Date:  1993-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  417-23     Citation Subset:  IM    
Nathan S. Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962.
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MeSH Terms
Amino Acids / analysis*,  metabolism
Brain / growth & development*
Brain Chemistry*
Tissue Distribution
Reg. No./Substance:
0/Amino Acids

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