| Heterogeneous distribution of endothelium-dependent relaxations resistant to NG-nitro-L-arginine in rats. | |
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MedLine Citation:
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PMID: 1415757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelium-dependent relaxations that are resistant to inhibitors of nitric oxide synthase probably are mediated by endothelium-dependent hyperpolarization of the vascular smooth muscle. Experiments were performed to examine the distribution of this type of relaxation along the arterial tree of the rat by measuring changes in isometric force. Acetylcholine induced concentration- and endothelium-dependent relaxations in aortas and in pulmonary, common iliac, femoral, mesenteric, and renal arteries contracted with phenylephrine. In the presence of NG-nitro-L-arginine, the cumulative administration of acetylcholine induced relaxations only in the femoral, mesenteric, and renal arteries. The calcium ionophore A23187 relaxed mesenteric arteries contracted with phenylephrine in a concentration- and endothelium-dependent manner. The concentration-relaxation curve to A23187 was shifted to the right in the presence of NG-nitro-L-arginine. The maximal relaxations induced by lemakalim, a K+ channel opener, were smaller in those arteries that did not exhibit NG-nitro-L-arginine-resistant relaxations. These results suggest that NG-nitro-L-arginine-resistant relaxations are more frequently observed in smaller arteries. The arteries that exhibit NG-nitro-L-arginine-resistant relaxations may be more sensitive to an endothelium-derived substance that causes hyperpolarization of vascular smooth muscle cells. |
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Authors:
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T Nagao; S Illiano; P M Vanhoutte |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 263 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1090-4 Citation Subset: IM |
Affiliation:
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Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Arginine / analogs & derivatives*, pharmacology Arteries / drug effects Calcimycin / pharmacology Endothelium, Vascular / physiology* Male Nitroarginine Phenylephrine / pharmacology Rats Rats, Wistar Vasodilation / drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-31183/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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2149-70-4/Nitroarginine; 51-84-3/Acetylcholine; 52665-69-7/Calcimycin; 59-42-7/Phenylephrine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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