Document Detail

Heterogeneous diversity of spacers within CRISPR (clustered regularly interspaced short palindromic repeats).
MedLine Citation:
PMID:  20867676     Owner:  NLM     Status:  MEDLINE    
Clustered regularly interspaced short palindromic repeats (CRISPR) in bacterial and archaeal DNA have recently been shown to be a new type of antiviral immune system in these organisms. We here study the diversity of spacers in CRISPR under selective pressure. We propose a population dynamics model that explains the biological observation that the leader-proximal end of CRISPR is more diversified and the leader-distal end of CRISPR is more conserved. This result is shown to be in agreement with recent experiments. Our results show that the CRISPR spacer structure is influenced by and provides a record of the viral challenges that bacteria face.
Jiankui He; Michael W Deem
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Publication Detail:
Type:  Journal Article     Date:  2010-09-14
Journal Detail:
Title:  Physical review letters     Volume:  105     ISSN:  1079-7114     ISO Abbreviation:  Phys. Rev. Lett.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401141     Medline TA:  Phys Rev Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128102     Citation Subset:  IM    
Department of Physics and Astronomy, Rice University, Houston, Texas 77005, USA.
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MeSH Terms
Bacteria / classification,  genetics*,  metabolism
Cluster Analysis
DNA, Bacterial / genetics,  physiology
DNA, Intergenic / genetics*,  physiology
Genome, Bacterial / genetics*,  physiology
Inverted Repeat Sequences*
Polymorphism, Genetic
Time Factors
Reg. No./Substance:
0/DNA, Bacterial; 0/DNA, Intergenic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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