| Heterogeneous diversity of spacers within CRISPR (clustered regularly interspaced short palindromic repeats). | |
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MedLine Citation:
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PMID: 20867676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clustered regularly interspaced short palindromic repeats (CRISPR) in bacterial and archaeal DNA have recently been shown to be a new type of antiviral immune system in these organisms. We here study the diversity of spacers in CRISPR under selective pressure. We propose a population dynamics model that explains the biological observation that the leader-proximal end of CRISPR is more diversified and the leader-distal end of CRISPR is more conserved. This result is shown to be in agreement with recent experiments. Our results show that the CRISPR spacer structure is influenced by and provides a record of the viral challenges that bacteria face. |
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Authors:
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Jiankui He; Michael W Deem |
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Publication Detail:
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Type: Journal Article Date: 2010-09-14 |
Journal Detail:
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Title: Physical review letters Volume: 105 ISSN: 1079-7114 ISO Abbreviation: Phys. Rev. Lett. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401141 Medline TA: Phys Rev Lett Country: United States |
Other Details:
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Languages: eng Pagination: 128102 Citation Subset: IM |
Affiliation:
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Department of Physics and Astronomy, Rice University, Houston, Texas 77005, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
/
classification,
genetics*,
metabolism Cluster Analysis DNA, Bacterial / genetics, physiology DNA, Intergenic / genetics*, physiology Genome, Bacterial / genetics*, physiology Inverted Repeat Sequences* Polymorphism, Genetic Time Factors |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial; 0/DNA, Intergenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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