| Heterogeneity and prognostic significance of macrophages in human colonic carcinomas. | |
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MedLine Citation:
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PMID: 4027996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previously, we reported that high concentrations of eosinophils in human colonic carcinomas are associated with better prognoses, that sections taken 1 cm remote from (deep to) the margin of tumor (SRM) and sections contiguous to the margin (SCM) of tumor and adjacent uninvolved colon contain significantly different concentrations of eosinophils, and that concentrations of eosinophils in SCM and SRM are both useful and complementary for the prediction of prognosis. As a first step towards studying the ecology of the eosinophil in colonic carcinoma and with the goal of identifying other kinds of cells that might be useful for the prediction of prognosis, we counted cells in SCM and SRM that expressed histochemically demonstrable acid phosphatase, alpha-naphthylbutyrate esterase, and peroxidase. The tumors of patients with and without metastases at the time of resection of the primary tumor contained different (P = 0.0314) concentrations of cells with histochemically demonstrable alpha-naphthylbutyrate esterase in SCM but not in SRM. In contiguous 1- to 2-micron sections, morphologically macrophage-like cells with histochemically demonstrable acid phosphatase and cells with histochemically demonstrable alpha-naphthylbutyrate esterase were found to be present in different concentrations both in SCM (P less than 0.01) and in SRM (P less than 0.01); i.e., these phenotypic markers appear to identify different subpopulations of macrophages in tumors. In contrast to our previous study of human pulmonary alveolar macrophages, examination of sections stained sequentially for these phenotypic markers that are commonly used for the identification of macrophages in tumors revealed numerous cells in the same sections that expressed histochemically demonstrable acid phosphatase (red) but not alpha-naphthyl butyrate esterase (brown) and vice versa. Several of these markers promise to be useful and complementary for the prediction of prognosis. |
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Authors:
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E L Luebbers; T P Pretlow; S N Emancipator; E A Boohaker; A M Pitts; A J Macfadyen; E L Bradley; T G Pretlow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 45 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-10-23 Completed Date: 1985-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5196-200 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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analysis Carboxylic Ester Hydrolases / analysis Colonic Neoplasms / pathology* Humans Macrophages / enzymology, pathology* Peroxidases / analysis Prognosis Receptors, Fc / analysis |
| Grant Support | |
ID/Acronym/Agency:
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CA-13148/CA/NCI NIH HHS; CA-31140/CA/NCI NIH HHS; CA-36467/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Fc; EC 1.11.1.-/Peroxidases; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/naphthylbutyrate esterase; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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