Document Detail


Heterogeneity of pathogenetic mechanisms in aplastic anemia. Efficacy of therapy based on in-vitro results.
MedLine Citation:
PMID:  6972718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms responsible for the bone marrow failure in 21 aplastic anemia patients were studied by the colony-forming units in culture assay (CFU-C). Twelve patients had no detectable in-vitro defect that could be responsible for the low CFU-C numbers. Three patients had suppressor T cells that inhibited CFU-C (p less than 0.001); one of two patients responded to antithymocyte globulin therapy and the third recovered spontaneously. Three patients had serum inhibitory immunoglobulins directed against their marrow CFU-C; plasmapheresis resulted in recovery of bone marrow function. Three patients had abnormalities at the colony-stimulating factor level: Two had inhibitors of colony-stimulating factor, corrected in vitro and in vivo by indomethacin and cholinergic agonists (p less than 0.01); and the third had colony-stimulating factor generation defect, corrected in vitro and in vivo by lithium. Testing for cellular or humoral suppressor factors directed against precursor cells or for abnormalities at the colony-stimulating factor level gives helpful guidelines to therapy in aplastic anemia.
Authors:
N I Abdou; J D Verdirame; M Amare; N L Abdou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  95     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anemia, Aplastic / etiology*
Bone Marrow / pathology
Child
Colony-Forming Units Assay
Colony-Stimulating Factors / physiology
Female
Hematopoiesis
Humans
Leukocyte Count
Male
Middle Aged
T-Lymphocytes / physiology
Grant Support
ID/Acronym/Agency:
AI-15360/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Colony-Stimulating Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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