Document Detail

Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT.
MedLine Citation:
PMID:  15332387     Owner:  NLM     Status:  MEDLINE    
Asthmatic airway narrowing is heterogeneous and contributes to airway hyperresponsiveness. The present study compared heterogeneity of narrowing during methacholine challenge in asthmatics and normal subjects using high-resolution computed tomography (HRCT). The current authors defined heterogeneity as variability in narrowing greater than the repeatability of measurement. Airways of <2 mm diameter were compared with larger airways from baseline and postmethacholine HRCT of the right lower lung in 13 normals (seven had repeat baseline scans) and seven asthmatics. The coefficient of repeatability was calculated from repeat scans (RepAi) and was compared with heterogeneity of narrowing measured by the variability in narrowing from pre versus postmethacholine scans (VardeltaAi). Forced expiratory volume in one second decreased 27+/-6% and 24+/-8% in normals and asthmatics, respectively. Airways >2 mm narrowed more heterogeneously in asthmatics (VardeltaAi=+/-0.85 mm) compared with normals (VardeltaAi=+/-0.67 mm), with both being greater than the measure of repeatability (RepAi=+/-0.16 mm). Small airway narrowing was not heterogeneous in asthmatics (VardeltaAi=+/-0.59 mm) or normals (VardeltaAi=+/-0.53 mm) compared with repeatability (RepAi=0.51 mm). It is possible to study heterogeneity of airway narrowing in small and large airways using high resolution computed tomography. Airway narrowing is heterogeneous in the large airways of asthmatics and normals, being greater in asthmatics.
G G King; J D Carroll; N L Müller; K P Whittall; M Gao; Y Nakano; P D Paré
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  24     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-11-30     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  211-8     Citation Subset:  IM    
University of British Columbia, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Sydney, Australia.
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MeSH Terms
Airway Resistance / drug effects*
Analysis of Variance
Asthma / pathology*,  radiography
Bronchial Hyperreactivity / diagnosis*
Bronchial Provocation Tests
Bronchoconstriction / drug effects
Case-Control Studies
Image Interpretation, Computer-Assisted*
Lung Volume Measurements
Methacholine Chloride / adverse effects,  diagnostic use*
Middle Aged
Reference Values
Respiratory Function Tests
Tomography, X-Ray Computed / methods
Reg. No./Substance:
62-51-1/Methacholine Chloride
Comment In:
Eur Respir J. 2004 Aug;24(2):193-4   [PMID:  15332382 ]

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