| Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT. | |
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MedLine Citation:
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PMID: 15332387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asthmatic airway narrowing is heterogeneous and contributes to airway hyperresponsiveness. The present study compared heterogeneity of narrowing during methacholine challenge in asthmatics and normal subjects using high-resolution computed tomography (HRCT). The current authors defined heterogeneity as variability in narrowing greater than the repeatability of measurement. Airways of <2 mm diameter were compared with larger airways from baseline and postmethacholine HRCT of the right lower lung in 13 normals (seven had repeat baseline scans) and seven asthmatics. The coefficient of repeatability was calculated from repeat scans (RepAi) and was compared with heterogeneity of narrowing measured by the variability in narrowing from pre versus postmethacholine scans (VardeltaAi). Forced expiratory volume in one second decreased 27+/-6% and 24+/-8% in normals and asthmatics, respectively. Airways >2 mm narrowed more heterogeneously in asthmatics (VardeltaAi=+/-0.85 mm) compared with normals (VardeltaAi=+/-0.67 mm), with both being greater than the measure of repeatability (RepAi=+/-0.16 mm). Small airway narrowing was not heterogeneous in asthmatics (VardeltaAi=+/-0.59 mm) or normals (VardeltaAi=+/-0.53 mm) compared with repeatability (RepAi=0.51 mm). It is possible to study heterogeneity of airway narrowing in small and large airways using high resolution computed tomography. Airway narrowing is heterogeneous in the large airways of asthmatics and normals, being greater in asthmatics. |
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Authors:
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G G King; J D Carroll; N L Müller; K P Whittall; M Gao; Y Nakano; P D Paré |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 24 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-30 Completed Date: 2004-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
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Languages: eng Pagination: 211-8 Citation Subset: IM |
Affiliation:
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University of British Columbia, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Sydney, Australia. ggk@woolcock.org.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance / drug effects* Analysis of Variance Asthma / pathology*, radiography Bronchial Hyperreactivity / diagnosis* Bronchial Provocation Tests Bronchoconstriction / drug effects Case-Control Studies Humans Image Interpretation, Computer-Assisted* Lung Volume Measurements Male Methacholine Chloride / adverse effects, diagnostic use* Middle Aged Probability Reference Values Respiratory Function Tests Tomography, X-Ray Computed / methods |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2004 Aug;24(2):193-4
[PMID:
15332382
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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