Document Detail


Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex.
MedLine Citation:
PMID:  20484645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recent discovery of short neural precursors (SNPs) in the murine neocortical ventricular zone (VZ) challenges the widely held view that radial glial cells (RGCs) are the sole occupants of this germinal compartment and suggests that precursor variety is an important factor of brain development. Here, we use in utero electroporation and genetic fate mapping to show that SNPs and RGCs cohabit the VZ but display different cell cycle kinetics and generate phenotypically different progeny. In addition, we find that RGC progeny undergo additional rounds of cell division as intermediate progenitor cells (IPCs), whereas SNP progeny generally produce postmitotic neurons directly from the VZ. By clearly defining SNPs as bona fide VZ residents, separate from both RGCs and IPCs, and uncovering their unique proliferative and lineage properties, these results demonstrate how individual neural precursor groups in the embryonic rodent VZ create diversity in the overlying neocortex.
Authors:
Elizabeth K Stancik; Ivan Navarro-Quiroga; Robert Sellke; Tarik F Haydar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-06-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7028-36     Citation Subset:  IM    
Affiliation:
Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Transport System X-AG / genetics
Analysis of Variance
Animals
Animals, Newborn
Bromodeoxyuridine / metabolism
Cell Cycle / physiology*
Cerebral Ventricles / cytology*,  embryology,  growth & development
Electroporation / methods
Eye Proteins / metabolism
Gene Expression Regulation, Developmental / genetics*
Green Fluorescent Proteins / genetics
Homeodomain Proteins / metabolism
Ki-67 Antigen / metabolism
Luminescent Proteins / genetics
Mice
Mice, Inbred ICR
Mice, Transgenic
Neocortex / cytology*
Nerve Tissue Proteins / metabolism
Neuroglia / metabolism
Neurons / physiology*
POU Domain Factors / metabolism
Paired Box Transcription Factors / metabolism
Repressor Proteins / metabolism
Stem Cells / physiology*
T-Box Domain Proteins / metabolism
Tubulin / metabolism
Grant Support
ID/Acronym/Agency:
NS051852/NS/NINDS NIH HHS; P30HD40677/HD/NICHD NIH HHS; R01 NS051852-05/NS/NINDS NIH HHS; R01 NS051852-06/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acid Transport System X-AG; 0/Eomes protein, mouse; 0/Eye Proteins; 0/Homeodomain Proteins; 0/Ki-67 Antigen; 0/Luminescent Proteins; 0/Nerve Tissue Proteins; 0/PAX6 protein; 0/POU Domain Factors; 0/Paired Box Transcription Factors; 0/Repressor Proteins; 0/T-Box Domain Proteins; 0/Tubulin; 0/beta3 tubulin, mouse; 0/red fluorescent protein; 147258-10-4/Pou3f3 protein, mouse; 147336-22-9/Green Fluorescent Proteins; 59-14-3/Bromodeoxyuridine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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