Document Detail


Heterogeneity in the transforming growth factor beta response of esophageal cancer cells.
MedLine Citation:
PMID:  12012005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of the transforming growth factor beta (TGFbeta) pathway in the development and progression of esophageal cancers is poorly understood. As an initial step in clarification of this issue, the functional status of the TGFbeta pathway was evaluated in a panel of esophageal cancer derived cell lines. Both adenocarcinoma and squamous cell carcinoma derived lines were represented. Although the TGFbeta pathway was intact and functional in four of the five cell lines, only one of them was growth inhibited by TGFbeta. In one cell line, the loss of a growth inhibitory response to TGFbeta could be explained by decreased expression of Smad 4 and a general inability to activate TGFbeta responsive promoters. In the other three cell lines, TGFbeta was able to activate transcription of TGFbeta responsive promoters, but unable to downregulate transcription of c-myc. Taken together these findings indicate that a selective loss in the ability of TGFbeta to regulate expression of a key component of the growth inhibitory pathway may contribute to the poor prognosis of esophageal cancers.
Authors:
Deborah A Lebman; Jeffery S Edmiston; Theodore D Chung; Steven R Snyder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oncology     Volume:  20     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1241-6     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond 23298-0678, USA. dlebman@hsc.vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Down-Regulation
Esophageal Neoplasms / drug therapy*,  metabolism,  pathology
Genes, myc
Humans
Transforming Growth Factor beta / pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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