Document Detail

Heterogeneity in terms of interleukin 4-dependent regulation of Fc epsilon...receptor/CD23 expression on chronic B-lymphocytic leukemia cells.
MedLine Citation:
PMID:  2523867     Owner:  NLM     Status:  MEDLINE    
To discriminate the stages of maturation arrest of leukemic B cells, we have investigated the cell surface expression of Fc epsilon RII (H107 antigen) on leukemic B cells from 6 patients with chronic type B-lymphocytic leukemia (B-CLL) by a double staining method combined with cytofluorometry, and their production of soluble Fc epsilon RII by an ELISA technique. Fc epsilon RII was expressed on mu+/delta- cells of case 5 as well as on mu+/delta+ cells of cases 1, 2 and 4, but not on mu+/delta+ cells in cases 3 and 6. The cultivation of leukemic cells with IL-4 not only increased the percentage of Fc epsilon RII+ cells but also enhanced the production of soluble Fc epsilon RII+ in most cases. However, IL-4 had no effects on mu+/delta-/Fc epsilon RII+ cells of case 5, which appeared to correspond to a rather late stage of normal B cell differentiation. Moreover, while leukemic B cells from case 1 spontaneously produced large amounts of soluble Fc epsilon R, the release seemed to be inhibited by an addition of IL-4. From our observations, it is speculated that IgM+/IgD+/Fc epsilon RII- leukemic B cells express surface membrane Fc epsilon RII and produce soluble Fc epsilon RII following stimulation with IL-4, and that IgM+/IgD-/Fc epsilon RII+ B-CLL cells may exist at some late stage of B cell differentiation.
H Ishida; S Kumagai; K Iwai; T Takahashi; T Kawabe; J Yodoi; N Arai; S Namiuchi; Y Konaka; H Imura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology letters     Volume:  20     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-12     Completed Date:  1989-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Second Division of Internal Medicine, Kyoto University, Japan.
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MeSH Terms
Antigens, Differentiation, B-Lymphocyte / immunology*
Cell Separation
Dose-Response Relationship, Immunologic
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Interleukins / pharmacology*
Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
Middle Aged
Receptors, Fc / immunology*
Receptors, IgE
Reg. No./Substance:
0/Antigens, Differentiation, B-Lymphocyte; 0/Interleukins; 0/Receptors, Fc; 0/Receptors, IgE; 207137-56-2/Interleukin-4

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