Document Detail

Heterogeneity in progressive aphasia due to focal cortical atrophy. A clinical and PET study.
MedLine Citation:
PMID:  2245299     Owner:  NLM     Status:  MEDLINE    
Six patients with a slowly progressive aphasic disorder due to degenerative cortical disease are reported. The length of history varied from 18 months to 6 years. In 5 patients, there was a naming deficit, associated in 4 of these with some abnormalities in comprehension. One patient had a progressive history of reduced speech output, which was associated with an orofacial dyspraxia. All patients were studied neuropsychologically, and in addition regional cerebral metabolism was measured using position emission tomography. A localized left hemisphere deficit was found in all patients except 1, who had the longest history and the most profound clinical deficit, and who also had right hemisphere hypometabolism. The major brunt of the deficit was in the anterior portion of the left temporal lobe in all but 1 case, the patient with poor speech output who had a more severe left posterior frontal deficit. These findings suggest that in progressive aphasia due to focal cortical atrophy there is heterogeneity in the clinical presentation and anatomical site of the deficit, with possible implications for the underlying aetiology.
P J Tyrrell; E K Warrington; R S Frackowiak; M N Rossor
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  113 ( Pt 5)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-01-10     Completed Date:  1991-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1321-36     Citation Subset:  AIM; IM    
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
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MeSH Terms
Aphasia / etiology*
Brain / metabolism
Brain Diseases / complications,  diagnosis
Cerebral Cortex / metabolism,  pathology*,  radiography
Cerebrovascular Circulation
Magnetic Resonance Imaging
Middle Aged
Oxygen Consumption
Tissue Distribution
Tomography, Emission-Computed*
Tomography, X-Ray Computed

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