Document Detail

Heterogeneity in human IFN-γ responses to clinical Mycobacterium tuberculosis strains.
MedLine Citation:
PMID:  20835598     Owner:  NLM     Status:  MEDLINE    
Mycobacterium tuberculosis is one of the most successful human pathogens. Highly virulent strains, which are more easily transmitted than are less virulent strains, elicit variable immune responses. We evaluated the Th1 responses (IFN-γ production) in healthy volunteers after stimulation with various strains. Our results show that the individuals with negative tuberculin skin test (TST) results were not necessarily naive to all of the strains tested, whereas individuals with positive TST results did not respond to all of the strains tested. Drug-resistant strains induced a lower mean level of IFN-γ production than did drug-sensitive strains. One possible practical application of this finding would be for the prediction of responses to treatment, in which it might be advantageous to have knowledge of the estimated IFN-γ production elicited by a specific isolated strain.
Vinícius Ribeiro Cabral; Cláudia Ferreira de Souza; Fernanda Luiza Pedrosa Guimarães; Maria Helena Feres Saad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia     Volume:  36     ISSN:  1806-3756     ISO Abbreviation:  J Bras Pneumol     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-05-13     Revised Date:  2011-10-11    
Medline Journal Info:
Nlm Unique ID:  101222274     Medline TA:  J Bras Pneumol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  494-7     Citation Subset:  IM    
Laboratório de Microbiologia Celular, Fundação Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
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MeSH Terms
Interferon-gamma / biosynthesis*
Mycobacterium tuberculosis / isolation & purification,  pathogenicity*
Th1 Cells / immunology*
Reg. No./Substance:

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