Document Detail


Heterogeneity in 1H-MRS profiles of presymptomatic and early manifest Huntington's disease.
MedLine Citation:
PMID:  15621015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate (1)H-MRS profiles of the putamen in presymptomatic and manifest Huntington's disease (HD) patients for spectroscopic markers that are reliable, consistent signs of early pathology and to look for hemispheric differences as signs of use activation in an accelerated degradative process of the dominant hemisphere. METHODS: A short echo time Point RESolved Spectroscopy (PRESS) spectroscopic imaging study was performed at low field (0.5 Tesla, T) on 27 right-handed patients (17 presymptomatic gene carriers and 10 manifest patients of less than 3 years from clinical onset) and 10 right-handed normal volunteers. Spectra from individual voxels (0.56 cm(3)) in the putamen were selected for analysis. Resonance areas of peaks were normalized to water as a concentration standard. Interhemispheric comparisons were made in individuals in all three groups to look for hemispheric differences. RESULTS: Two presymptomatic patients showed normal spectra but all other HD patients displayed some combination of reduced N-acetylaspartate (NAA), enhanced glutamate/glutamine (Glx) activity, and lactate (Lac) elevations or reduced creatine (Cr). Rather than showing any one metabolite as pathognomonic of early change, spectroscopic profiles showed heterogeneity between HD patients. Low creatine was common in the presymptomatic but not in the manifest group. Hemispheric ratios of abnormal metabolites showed lower values of NAA and Glx in the dominant hemisphere in all three groups but values of creatine were selectively lower in the dominant hemisphere of only the presymptomatic patients. Lac was elevated in both hemispheres but less so in the dominant hemisphere in all HD patients. CONCLUSIONS: (1)H-MRS profiles from the putamen of presymptomatic and manifest patients reflect heterogeneity in pathophysiology. With the possible exception of low creatine in presymptomatic patients (1)H-MRS spectra are not suggestive of hemispheric differences supportive of an overall accelerated degradative process in the dominant hemisphere.
Authors:
Norman C Reynolds; Robert W Prost; Leighton P Mark
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  1031     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  82-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, The Medical College of Wisconsin, Froedtert Lutheran Memorial Hospital, 8700 Watertown Plank Road, Milwaukee, WI 53226, USA. nreynjr@pol.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Aspartic Acid / analogs & derivatives*,  metabolism
Early Diagnosis
Female
Glutamic Acid / metabolism
Glutamine / metabolism
Humans
Huntington Disease / metabolism*,  pathology*
Magnetic Resonance Spectroscopy*
Male
Middle Aged
Protons
Putamen / metabolism*,  pathology*
Chemical
Reg. No./Substance:
0/Protons; 56-84-8/Aspartic Acid; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 997-55-7/N-acetylaspartate

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