Document Detail

Heterogeneity of the hypoxic state in rat heart is determined at capillary level.
MedLine Citation:
PMID:  8447446     Owner:  NLM     Status:  MEDLINE    
Heterogeneity in the hypoxic state of Tyrode-perfused rat hearts was studied using NADH and Pd-porphine videofluorometry. Ischemic as well as high-flow anoxia resulted in a homogeneous rise of tissue NADH fluorescence, whereas normoxic recovery from both types of anoxia caused transiently persisting patchy fluorescent areas. Patterns were always the same for a given heart. PO2 distribution in the vasculature measured by Pd-porphine phosphorescence showed patterns similar to the NADH fluorescence patterns. Microsphere embolization of the capillaries, but not of arterioles, elicited identical NADH fluorescence patterns as seen during recovery from anoxia without microspheres. High heartbeat rates also caused patchy fluorescent areas but not in the presence of adenosine. Patterns corresponded to those seen during normoxic recovery from anoxia under low beat rates. It is concluded that there are circulatory units in the rat heart at the capillary level that result in the temporary persistence of anoxic areas during recovery from anoxia. These vulnerable areas are the first to be compromised during high heartbeat rates.
C Ince; J F Ashruf; J A Avontuur; P A Wieringa; J A Spaan; H A Bruining
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-06     Completed Date:  1993-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H294-301     Citation Subset:  IM    
Department of Surgery, Erasmus University of Rotterdam, The Netherlands.
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MeSH Terms
Cell Hypoxia / physiology*
Coronary Circulation*
Heart Rate
Luminescent Measurements
Microscopy, Fluorescence
Myocardium / metabolism
NAD / metabolism
Palladium / metabolism
Reference Values
Reg. No./Substance:
0/Mesoporphyrins; 0/Metalloporphyrins; 0/palladium-meso-tetra(4-carboxyphenyl)porphine; 53-84-9/NAD; 7440-05-3/Palladium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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