Document Detail

Heterogeneity of human eosinophils. II. Variability of respiratory burst activity related to cell density.
MedLine Citation:
PMID:  6467687     Owner:  NLM     Status:  MEDLINE    
Recent work has suggested that there may be heterogeneity amongst human eosinophils. In order to study this further, blood and tissue eosinophils were separated by density gradient centrifugation in discontinuous gradients of metrizamide. Blood eosinophils were obtained from 16 patients with blood eosinophil counts above 1 X 10(9)/l. Resident eosinophils were isolated from alveolar fluid in three of these patients and from pleural effusion in two others. A large proportion of the eosinophils in these patients were of light buoyant density (hypodense) and a high percentage of these showed morphological evidence of hypogranulation. Hypodense eosinophils had a reduced capacity to reduce nitroblue tetrazolium or develop chemiluminescence after stimulation with phorbol myristate acetate. It was concluded that there is structural and metabolic heterogeneity amongst blood and tissue eosinophils in patients with a variety of eosinophilic disorders.
L Prin; J Charon; M Capron; P Gosset; H Taelman; A B Tonnel; A Capron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  57     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-10-19     Completed Date:  1984-10-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  735-42     Citation Subset:  IM    
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MeSH Terms
Centrifugation, Density Gradient
Eosinophilia / metabolism
Eosinophils / metabolism*,  pathology
Leukocyte Count
Luminescent Measurements
Nitroblue Tetrazolium
Oxygen Consumption*
Pleural Effusion
Pulmonary Alveoli / pathology
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 298-83-9/Nitroblue Tetrazolium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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