Document Detail


Heterogeneity of genetic control of blood pressure in ethnically different populations.
MedLine Citation:
PMID:  10453107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We review the literature on statistical genetic analyses of blood pressure in samples from various ethnic backgrounds using different statistical methods and packages. We then provide the results of a complex segregation analysis performed on familial data on systolic and diastolic blood pressure in 2 ethnically different populations, Chuvashans and Turkmenians. Two types of major gene models were tested in the segregation analysis: Model type 1 tests for a Mendelian mode of transmission and estimates genotype-specific averages regardless of age and sex effect, and model type 2 estimates age and sex effects on each of 3 genotypes within the putative major genotype. In both total samples, by both types of segregation analysis, familial aggregation of both systolic and diastolic blood pressure was inconsistent with the Mendelian mode of inheritance. In the next step of analysis the pedigrees in both samples were sorted into 2 groups on the basis of 2 likelihoods as obtained under Mendelian and nontransmission models for each entire sample. This procedure resulted in the appearance of 2 subsamples (large and small) in each ethnic sample. The segregation analysis that was carried out then on the larger subsample provided consistent evidence to support the major gene effect on systolic and diastolic blood pressure in 2 ethnic groups. Interestingly, model type 2 showed that in both ethnically different large subsamples, for each sex the genotype predisposing to a larger mean value of systolic (or diastolic) blood pressure also displayed the highest rate of blood pressure increase with age. We discuss in detail possible sources of heterogeneity in familial transmission of blood pressure observed in our 2 samples, and we suggest a method to improve the analysis of heterogeneity for trait inheritance.
Authors:
G Livshits; E Ginsburg; E Kobyliansky
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Human biology     Volume:  71     ISSN:  0018-7143     ISO Abbreviation:  Hum. Biol.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-21     Completed Date:  1999-09-21     Revised Date:  2011-04-18    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  685-708     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Blood Pressure / genetics*
Female
Genetic Heterogeneity*
Genotype
Humans
Hypertension / ethnology*,  genetics*
Likelihood Functions
Male
Middle Aged
Models, Genetic
Pedigree
Russia / epidemiology
Turkmenistan / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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