| Heterogeneity of fetal hemoglobin in severe alpha-thalassemia. | |
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MedLine Citation:
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PMID: 486608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The heterogeneity of residue 136 of the gamma-chain of human hemoglobin has been determined for a patient afflicted with severe alpha-thalassemia. Separation of the cord blood sample into the various constituent hemoglobins A, F, FI and Bart's were done on a column packed with DEAE Sephadex. The amount of glycine or alanine at position 136 was determined for hemoglobins F, FI and Bart's. The ratios determined for all three hemoglobins indicated that the G gamma/A gamma ratio is the same for all three fractions and is similar to that observed in normal cord blood samples. |
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Authors:
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T S Vedvick; S A Wheeler; H M Koenig |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of the neonate Volume: 36 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1979 |
Date Detail:
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Created Date: 1979-12-18 Completed Date: 1979-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 181-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Fetal Blood / analysis Fetal Hemoglobin / analysis*, genetics Hemoglobin A / analysis Hemoglobin H / analysis Humans Infant, Newborn Thalassemia / blood* |
| Chemical | |
Reg. No./Substance:
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9034-51-9/Hemoglobin A; 9034-63-3/Fetal Hemoglobin; 9034-79-1/Hemoglobin H |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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