Document Detail

Heterogeneity of cytokine single-nucleotide polymorphisms among the Iranian and in the other East-South Asian populations.
MedLine Citation:
PMID:  16764598     Owner:  NLM     Status:  MEDLINE    
Cytokine gene polymorphisms may affect their transcription, influence their level of production and may be implicated in inducing susceptibility or resistance to diseases. In 40 Iranian healthy subjects, cytokine single-nucleotide polymorphisms (SNPs) were used to determine allelic and genotypic frequencies for the following cytokine genes: IL-1a (T/C -889), IL-1beta (C/T -511, T/C 3962), IL-12 (C/A -1188), IFN-gamma (A/T UTR 5644), TGF-beta (C/T codon 10, G/C codon 25), TNF-a (G/A -308, G/A -238), IL-2 (T/G -330, G/T 166), IL-4 (T/G -1089, T/C -590, T/C -33), IL-6 (G/C -174, G/A nt565), IL-10 (G/A -1082, C/T -819, C/A -592), IL-1R (C/T pst11970), IL-1RA (T/C mspa111100) and IL-4RA (G/A 1902). All typing were performed with polymerase chain reaction with sequence specific primers assay. Significant heterogeneity of cytokine SNPs among the Iranian and the other East-South Asian populations was observed. Heterogeneity of cytokine SNPs may explain the role of natural selection in susceptibilities of populations to different disorders.
M Bagheri; I Abdi-Rad; D Omrani; H R Khalkhali
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Publication Detail:
Type:  Journal Article; Retracted Publication    
Journal Detail:
Title:  Transfusion medicine (Oxford, England)     Volume:  16     ISSN:  0958-7578     ISO Abbreviation:  Transfus Med     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-09-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9301182     Medline TA:  Transfus Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-9     Citation Subset:  IM    
Genetic Department, Faculty of Medicine, Uremia Medical Sciences University, Uremia, Iran.
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MeSH Terms
Asia, Southeastern / epidemiology
Cytokines / genetics*
Gene Frequency
Genetic Heterogeneity*
Iran / epidemiology
Molecular Epidemiology
Polymorphism, Single Nucleotide*
Reg. No./Substance:
Retraction In:
Bagheri M. Transfus Med. 2006 Dec;16(6):439   [PMID:  17163875 ]

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