Document Detail


Heterogeneity of cytokine single-nucleotide polymorphisms among the Iranian and in the other East-South Asian populations.
MedLine Citation:
PMID:  16764598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokine gene polymorphisms may affect their transcription, influence their level of production and may be implicated in inducing susceptibility or resistance to diseases. In 40 Iranian healthy subjects, cytokine single-nucleotide polymorphisms (SNPs) were used to determine allelic and genotypic frequencies for the following cytokine genes: IL-1a (T/C -889), IL-1beta (C/T -511, T/C 3962), IL-12 (C/A -1188), IFN-gamma (A/T UTR 5644), TGF-beta (C/T codon 10, G/C codon 25), TNF-a (G/A -308, G/A -238), IL-2 (T/G -330, G/T 166), IL-4 (T/G -1089, T/C -590, T/C -33), IL-6 (G/C -174, G/A nt565), IL-10 (G/A -1082, C/T -819, C/A -592), IL-1R (C/T pst11970), IL-1RA (T/C mspa111100) and IL-4RA (G/A 1902). All typing were performed with polymerase chain reaction with sequence specific primers assay. Significant heterogeneity of cytokine SNPs among the Iranian and the other East-South Asian populations was observed. Heterogeneity of cytokine SNPs may explain the role of natural selection in susceptibilities of populations to different disorders.
Authors:
M Bagheri; I Abdi-Rad; D Omrani; H R Khalkhali
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Publication Detail:
Type:  Journal Article; Retracted Publication    
Journal Detail:
Title:  Transfusion medicine (Oxford, England)     Volume:  16     ISSN:  0958-7578     ISO Abbreviation:  Transfus Med     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-09-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9301182     Medline TA:  Transfus Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-9     Citation Subset:  IM    
Affiliation:
Genetic Department, Faculty of Medicine, Uremia Medical Sciences University, Uremia, Iran. mortaza_bagheri_sa@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Asia, Southeastern / epidemiology
Cytokines / genetics*
Gene Frequency
Genetic Heterogeneity*
Humans
Iran / epidemiology
Molecular Epidemiology
Polymorphism, Single Nucleotide*
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections
Retraction In:
Bagheri M. Transfus Med. 2006 Dec;16(6):439   [PMID:  17163875 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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