Document Detail

Heterogeneity of class I and class II MHC sequences in Schistosoma mansoni.
MedLine Citation:
PMID:  16470417     Owner:  NLM     Status:  MEDLINE    
We investigated the genetic variations in class I and class II major histocompatibility complex (MHC) genes of Schistosoma mansoni and the effects of host MHC genotypes. S. mansoni was maintained in combinations of two mouse strains with different MHC genotypes, and the MHC gene sequences of the cercariae were investigated. The detected class I MHC gene sequences were variable, with high similarity between the H-2D(b) murine host and the parasite. For other combinations, however, the parasite sequence was homologous to those of anthropoids. All class II MHC sequences detected in S. mansoni were homologous to those of anthropoids. Our results suggest that the genetic variation in the MHC sequences of S. mansoni is derived in part from the current host, indicating horizontal transfer of the sequences from mammal to parasite.
Ayumi Okada; Atsuko Imase; Hajime Matsuda; Hiroshi Ohmae; Hidekazu Hata; Yukio Iwamura
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-02-10
Journal Detail:
Title:  Parasitology research     Volume:  99     ISSN:  0932-0113     ISO Abbreviation:  Parasitol. Res.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-04-07     Completed Date:  2006-12-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Center for Arts and Humanities, Ibaraki Prefectural University of Health Sciences, Ami 4669-2, Ami, Inashiki, Ibaraki, 300-0394, Japan.
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MeSH Terms
Gene Transfer, Horizontal
Genes, MHC Class I / genetics*
Genes, MHC Class II / genetics*
Genetic Variation
Host-Parasite Interactions / genetics
Mice, Inbred BALB C / genetics,  parasitology
Mice, Inbred C57BL / genetics,  parasitology
Schistosoma mansoni / genetics,  physiology*
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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