Document Detail

Heterogeneity of cardiac sympathetic nerve activity and systolic dysfunction in patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  11801697     Owner:  NLM     Status:  MEDLINE    
Cardiac sympathetic nerve activity is changed in patients with hypertrophic cardiomyopathy (HCM). However, the relationship between heterogeneity of this activity and systolic left ventricular dysfunction in patients with HCM is not well established. This study was performed to evaluate the sympathetic nerve activity in various cardiac regions and to investigate the relationship between cardiac dysfunction and heterogeneity of the cardiac sympathetic nerve activity in patients with HCM. METHODS: Cardiac sympathetic nerve activity was evaluated in 25 patients with HCM and 10 control subjects using planar imaging and SPECT by 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. With planar 123I-MIBG imaging, the heart-to-mediastinum activity ratios (H/M), at early (20 min) and delayed (3 h) acquisition, and the washout rate were calculated. Polar maps of the left ventricular myocardium were divided into 20 segments, and the dispersion (maximal to minimal values) and SD of uptake and the washout rate in 20 segments were calculated. RESULTS: The early H/M did not differ between the 2 groups. The delayed H/M was significantly lower and the washout rate of the whole heart was significantly higher in the HCM group than those in the control group. In patients with HCM, the delayed H/M, early uptake dispersion, and SD of early uptake showed good correlation with the left ventricular end-diastolic and end-systolic dimensions and the percentage of fractional shortening. A stepwise regression analysis revealed that the SD of early uptake was a powerful determinant for the percentage of fractional shortening in patients with HCM. CONCLUSION: These results suggest that the heterogeneity of regional cardiac sympathetic nerve activity may be correlated with cardiac dysfunction in patients with HCM.
Masami Shimizu; Hidekazu Ino; Masato Yamaguchi; Hidenobu Terai; Kenshi Hayashi; Kenichi Nakajima; Junichi Taki; Hiroshi Mabuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  43     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-21     Completed Date:  2002-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use
Cardiomyopathy, Hypertrophic / physiopathology*,  radionuclide imaging
Case-Control Studies
Heart / innervation*,  radionuclide imaging
Iodine Radioisotopes / diagnostic use
Middle Aged
Myocardial Contraction
Radiopharmaceuticals / diagnostic use
Regression Analysis
Sympathetic Nervous System / physiopathology*,  radionuclide imaging
Tomography, Emission-Computed, Single-Photon*
Ventricular Dysfunction, Left / physiopathology*,  radionuclide imaging
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 77679-27-7/3-Iodobenzylguanidine

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