Document Detail


Heterogeneity analysis of breast cancer families by using age at onset as a covariate.
MedLine Citation:
PMID:  1539592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An extension of the usual mixture model of heterogeneity (two family types, one with and one without linkage) is proposed by introducing age at onset as a covariate. The extended model defines age-dependent penetrances where the exact parametrization of age-at-onset distributions depends on the given genotype and family type (linked or unlinked). This extension was applied to breast cancer families. We postulated that the mean age at onset in individuals affected by the linked gene was lower than the mean age at onset in all other affected individuals. Linkage heterogeneity for breast cancer families was detected at a significance level of .003.
Authors:
C Mérette; M C King; J Ott
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  50     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-9     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Columbia University, New York, NY 10032.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Breast Neoplasms / epidemiology*,  genetics*
Chi-Square Distribution
Cluster Analysis
Female
Gene Expression
Genetic Variation / genetics*
Humans
Likelihood Functions
Linkage (Genetics) / genetics*
Middle Aged
Models, Genetic*
Polymorphism, Genetic*
Recombination, Genetic
Risk Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
CA27632/CA/NCI NIH HHS; HG00008/HG/NHGRI NIH HHS; MH44292/MH/NIMH NIH HHS
Comments/Corrections

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