Document Detail


Heterogeneities in regional volumes of distribution and flows in rabbit heart.
MedLine Citation:
PMID:  2109937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heterogeneity of volumes of distribution in the heart influences the rates of uptake and washout of substrates and metabolites; thus it is important to evaluate their variability in the normal heart. Several tracers were injected intravenously into anesthetized adult closed-chest rabbits, and time was allowed for equilibration in the heart. Tracer microspheres were injected into the left ventricular cavity at the apex for the measurement of regional flows, the chest was opened, another set of microspheres was injected, and the heart was frozen rapidly in situ with liquid nitrogen-cooled Freon-22. Each heart was divided into 72 pieces of less than 0.1 g weight, and the tracer content of each was determined by multichannel gamma-counting and the water content by desiccation. The regional myocardial flows were (closed chest) 0.62 +/- 0.16 ml.g-1.min-1 and (open chest) 0.63 +/- 0.37 ml.g-1.min-1. The volumes of distribution (ml/g) for the 432 pieces for six rabbits, given as mean +/- SD (% coefficient of variation), were as follows: for plasma, VP = 0.11 +/- 0.03 (26%); erythrocytes, VRBC = 0.041 +/- 0.015 (37%); vascular space, VV = 0.15 +/- 0.04 (26%); extracellular space, VECF = 0.33 +/- 0.05 (15%); interstitial space, VISF = 0.21 +/- 0.03 (15%); and water space, VW -0.79 +/- 0.022 (2.8%). Regional hematocrits were 77% +/- 9% of the large-vessel hematocrits.
Authors:
F Gonzalez; J B Bassingthwaighte
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-25     Completed Date:  1990-05-25     Revised Date:  2011-09-22    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1012-24     Citation Subset:  IM    
Affiliation:
Center for Bioengineering, University of Washington, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Volume*
Coronary Circulation*
Coronary Vessels / metabolism
Edetic Acid / metabolism
Extracellular Space / metabolism
Hematocrit
Male
Myocardium / metabolism*
Rabbits
Sodium / metabolism
Sucrose / metabolism
Time Factors
Tissue Distribution
Grant Support
ID/Acronym/Agency:
HL-19139/HL/NHLBI NIH HHS; R01 EB001973-25/EB/NIBIB NIH HHS; RR-01243/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
57-50-1/Sucrose; 60-00-4/Edetic Acid; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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