Document Detail

Heterocyclic systems containing the pyrimido-2,4-dione ring as selective ligands for the alpha 1-adrenoceptors.
MedLine Citation:
PMID:  7669185     Owner:  NLM     Status:  MEDLINE    
In the present paper recent results obtained in the field of the alpha 1-adrenoceptor (alpha 1AR) ligands are reported. Syntheses, alpha 1AR binding properties and structure-affinity relationships of tricyclic compounds containing the pyrimido-2,4-dione ring are described. Moreover, preliminary results on the binding properties of some derivatives for the recently cloned alpha 1AR subtypes expressed in COS-7 cells (alpha 1B, alpha 1C, alpha 1D) are discussed. Obtained data clearly indicate that some of the synthesized compounds are able to discriminate between the alpha 1B and the alpha 1C/alpha 1D adrenoceptor subclasses.
G Romeo; F Russo; S Guccione; D Barbarulo; A De Blasi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  50     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  471-7     Citation Subset:  IM    
Istituto di Chimica Farmaceutica e Tossicologica, Catania.
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MeSH Terms
Pyrimidinones / chemical synthesis*,  pharmacology
Receptors, Adrenergic, alpha-1 / antagonists & inhibitors*
Structure-Activity Relationship
Reg. No./Substance:
0/Ligands; 0/Pyrimidinones; 0/Receptors, Adrenergic, alpha-1

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