| Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells. | |
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MedLine Citation:
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PMID: 8625405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heterochronic genes control the timing of vulval development in the C. elegans hermaphrodite. lin-14 or lin-28 loss-of-function mutations cause the vulval precursor cells (VPCs) to enter S phase and to divide one larval stage earlier than in the wild type. A precocious vulva is formed by essentially normal cell lineage patterns, governed by the same intercellular signals as in the wild type. Mutations that prevent the normal developmental down-regulation of lin-14, activity delay or block VPC division and prevent vulval differentiation. A genetic pathway that includes lin-4, lin-14, and lin-28 controls when VPCs complete G1 and also controls when VPCs acquire the competence to respond to the intercellular patterning signals and express vulval fates. |
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Authors:
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S Euling; V Ambros |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 84 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-06-21 Completed Date: 1996-06-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 667-76 Citation Subset: IM |
Affiliation:
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Department of Cellular and Developmental Biology, Harvard University Cambridge, Massachusetts 02138, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / genetics*, growth & development* Cell Differentiation Cell Division Cell Nucleus / physiology DNA, Helminth / analysis Female Gene Expression Genes, Helminth* Genotype Hydroxyurea / pharmacology Mutation Phenotype Recombinant Proteins / biosynthesis Temperature Time Factors Vulva / cytology, growth & development* beta-Galactosidase / analysis, biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
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GM34028/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Helminth; 0/Recombinant Proteins; 127-07-1/Hydroxyurea; EC 3.2.1.23/beta-Galactosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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