Document Detail

Heterochromatin revisited.
MedLine Citation:
PMID:  17173056     Owner:  NLM     Status:  MEDLINE    
The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.
Shiv I S Grewal; Songtao Jia
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  8     ISSN:  1471-0056     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-46     Citation Subset:  IM    
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone / genetics,  metabolism
Ciliophora / genetics,  metabolism
Epigenesis, Genetic
Heterochromatin / genetics*,  metabolism*
Histones / genetics,  metabolism
Mammals / genetics,  metabolism
Models, Genetic
Plants / genetics,  metabolism
RNA Interference
Schizosaccharomyces / genetics,  metabolism
Schizosaccharomyces pombe Proteins / genetics,  metabolism
Reg. No./Substance:
0/Chromosomal Proteins, Non-Histone; 0/Heterochromatin; 0/Histones; 0/Schizosaccharomyces pombe Proteins; 107283-02-3/heterochromatin-specific nonhistone chromosomal protein HP-1

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