| Heterochromatin revisited. | |
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MedLine Citation:
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PMID: 17173056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions. |
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Authors:
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Shiv I S Grewal; Songtao Jia |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Nature reviews. Genetics Volume: 8 ISSN: 1471-0056 ISO Abbreviation: Nat. Rev. Genet. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-18 Completed Date: 2007-02-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962779 Medline TA: Nat Rev Genet Country: England |
Other Details:
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Languages: eng Pagination: 35-46 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. grewals@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone / genetics, metabolism Ciliophora / genetics, metabolism Epigenesis, Genetic Heterochromatin / genetics*, metabolism* Histones / genetics, metabolism Mammals / genetics, metabolism Models, Genetic Plants / genetics, metabolism RNA Interference Schizosaccharomyces / genetics, metabolism Schizosaccharomyces pombe Proteins / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Chromosomal Proteins, Non-Histone; 0/Heterochromatin; 0/Histones; 0/Schizosaccharomyces pombe Proteins; 107283-02-3/heterochromatin-specific nonhistone chromosomal protein HP-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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