Document Detail

Heterochromatin maintenance and establishment: lessons from the mouse pericentromere.
MedLine Citation:
PMID:  21941119     Owner:  NLM     Status:  MEDLINE    
Defined as a chromatin structure that remains condensed throughout the cell cycle heterochromatin is generally transcriptionally silent and is characterized by a specific molecular signature. Constitutive heterochromatin at the pericentromere is a conserved feature throughout evolution, which impacts genome stability. Here, we will summarize recent advances in our understanding of the dynamics of mouse pericentric heterochromatin during the cell cycle and development. Comparison with heterochromatin maintenance in fission yeast will enable discussions of the common basic principles and various mechanisms exploited in the distinct organisms.
Geneviève Almouzni; Aline V Probst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-01
Journal Detail:
Title:  Nucleus (Austin, Tex.)     Volume:  2     ISSN:  1949-1042     ISO Abbreviation:  Nucleus     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-10-28     Completed Date:  2012-03-06     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  101518322     Medline TA:  Nucleus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-8     Citation Subset:  IM    
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MeSH Terms
Cell Cycle
Centromere / metabolism,  physiology*
Heterochromatin / metabolism,  physiology*
Histones / metabolism
RNA, Untranslated / metabolism
Schizosaccharomyces / metabolism,  physiology
Reg. No./Substance:
0/Heterochromatin; 0/Histones; 0/RNA, Untranslated

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