| Heterochromatin maintenance and establishment: lessons from the mouse pericentromere. | |
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MedLine Citation:
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PMID: 21941119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Defined as a chromatin structure that remains condensed throughout the cell cycle heterochromatin is generally transcriptionally silent and is characterized by a specific molecular signature. Constitutive heterochromatin at the pericentromere is a conserved feature throughout evolution, which impacts genome stability. Here, we will summarize recent advances in our understanding of the dynamics of mouse pericentric heterochromatin during the cell cycle and development. Comparison with heterochromatin maintenance in fission yeast will enable discussions of the common basic principles and various mechanisms exploited in the distinct organisms. |
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Authors:
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Geneviève Almouzni; Aline V Probst |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-09-01 |
Journal Detail:
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Title: Nucleus (Austin, Tex.) Volume: 2 ISSN: 1949-1042 ISO Abbreviation: Nucleus Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-10-28 Completed Date: 2012-03-06 Revised Date: 2012-03-16 |
Medline Journal Info:
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Nlm Unique ID: 101518322 Medline TA: Nucleus Country: United States |
Other Details:
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Languages: eng Pagination: 332-8 Citation Subset: IM |
Affiliation:
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Institut Curie, Centre de Recherche, 26 rue d'Ulm, Paris F-75248, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle Centromere / metabolism, physiology* Heterochromatin / metabolism, physiology* Histones / metabolism Mice RNA, Untranslated / metabolism Schizosaccharomyces / metabolism, physiology |
| Chemical | |
Reg. No./Substance:
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0/Heterochromatin; 0/Histones; 0/RNA, Untranslated |
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