Document Detail

Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting.
MedLine Citation:
PMID:  22807219     Owner:  NLM     Status:  Publisher    
Heterobifunctional poly(ethylene glycol)s can be used for many biomedical applications ranging from solubility enhancement of hardly soluble compounds to surface modification of medical devices. In order to modify gold nanoparticles as model particles for drug targeting applications, PEG derivatives are synthesized that possess a high affinity for gold surfaces, namely a thioalkyl function, known to form stable monolayers on gold. Additionally a bisphosphonate function is introduced in the PEG molecule to allow targeting of hydroxyapatite rich tissues, like bone. Gold nanoparticles are modified using the synthesized bifunctional PEG and investigated for their stability in biological fluids and their ability to bind to hydroxyapatite granules in these fluids.
Gamal M S Zayed; Joerg K V Tessmar
Related Documents :
8728179 - Effect of different buffers on the biocompatibility of capd solutions.
12472529 - Artefacts produced by suture traction during incisional biopsy of oral lesions.
9093889 - Hemoperfusion with alpha-amanitin: an in vitro study.
21141429 - A re-examination of ambient air ozone monitor interferences.
7598649 - Albumin-based solutions for peritoneal dialysis: investigations with a rat model.
9068019 - Clinical and physiological effects of a new, less toxic and less acidic fluid for perit...
10958199 - Phantom materials for boron neutron capture therapy.
16600429 - Ethanol disinfection of plastic-adherent micro-organisms.
10536249 - Inhalation of tobramycin in cystic fibrosis. part 1: the choice of a nebulizer.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-16
Journal Detail:
Title:  Macromolecular bioscience     Volume:  -     ISSN:  1616-5195     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Department of Pharmaceutical Technology, University of Regensburg, 93040 Regensburg, Germany; Current Address: Department of Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Highly Stereo- and Regioselective Hydrostannylation of Internal Alkynes Promoted by Simple Boric Aci...
Next Document:  Clinical MRI of acute ischemic stroke.