| Hesperidin in orange juice reduces the absorption of celiprolol in rats. | |
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MedLine Citation:
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PMID: 18344215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that the intestinal absorption of celiprolol, an antihypertensive drug, is inhibited when it is taken with orange juice; it has been suggested that element(s) in citrus juice are responsible for this. In the present study, the pharmacokinetic interaction between celiprolol and orange juice was characterized through in vivo experiments with rats. Celiprolol 5 mg/kg was injected into the rat duodenum together with 5 ml/kg of neutralized orange juice or the same concentration of hesperidin as in the orange juice. Plasma celiprolol concentrations were measured by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). Concomitant administration of orange juice or hesperidin with celiprolol significantly decreased the area under the plasma concentration-time curve (AUC) by 74% and 75%, respectively, compared with control. These findings suggest that hesperidin is responsible for the decreased absorption of celiprolol and that orange juice taken with celiprolol has an inhibiting effect on intestinal absorption of the drug. |
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Authors:
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Yoshihiro Uesawa; Kiminori Mohri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 29 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-09 Completed Date: 2008-07-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: England |
Other Details:
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Languages: eng Pagination: 185-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. uesawa@my-pharm.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacokinetics* Area Under Curve Beverages Celiprolol / pharmacokinetics* Chromatography, Liquid Citrus sinensis / chemistry* Food-Drug Interactions* Hesperidin / pharmacology* Intestinal Absorption Male Rats Rats, Wistar Spectrometry, Mass, Electrospray Ionization |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 520-26-3/Hesperidin; 56980-93-9/Celiprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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