Document Detail

Hesperidin in orange juice reduces the absorption of celiprolol in rats.
MedLine Citation:
PMID:  18344215     Owner:  NLM     Status:  MEDLINE    
It has been reported that the intestinal absorption of celiprolol, an antihypertensive drug, is inhibited when it is taken with orange juice; it has been suggested that element(s) in citrus juice are responsible for this. In the present study, the pharmacokinetic interaction between celiprolol and orange juice was characterized through in vivo experiments with rats. Celiprolol 5 mg/kg was injected into the rat duodenum together with 5 ml/kg of neutralized orange juice or the same concentration of hesperidin as in the orange juice. Plasma celiprolol concentrations were measured by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). Concomitant administration of orange juice or hesperidin with celiprolol significantly decreased the area under the plasma concentration-time curve (AUC) by 74% and 75%, respectively, compared with control. These findings suggest that hesperidin is responsible for the decreased absorption of celiprolol and that orange juice taken with celiprolol has an inhibiting effect on intestinal absorption of the drug.
Yoshihiro Uesawa; Kiminori Mohri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  29     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-09     Completed Date:  2008-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  England    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  IM    
Department of Pharmaceutics, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacokinetics*
Area Under Curve
Celiprolol / pharmacokinetics*
Chromatography, Liquid
Citrus sinensis / chemistry*
Food-Drug Interactions*
Hesperidin / pharmacology*
Intestinal Absorption
Rats, Wistar
Spectrometry, Mass, Electrospray Ionization
Reg. No./Substance:
0/Antihypertensive Agents; 520-26-3/Hesperidin; 56980-93-9/Celiprolol

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