Document Detail

Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.
MedLine Citation:
PMID:  21068346     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although numerous human studies have shown consistent effects of some polyphenol-rich foods on several intermediate markers for cardiovascular diseases, it is still unknown whether their action could be specifically related to polyphenols.
OBJECTIVE: We investigated the effect of orange juice and its major flavonoid, hesperidin, on microvascular reactivity, blood pressure, and cardiovascular risk biomarkers through both postprandial and chronic intervention studies.
DESIGN: Twenty-four healthy, overweight men (age 50-65 y) were included in a randomized, controlled, crossover study. Throughout the three 4-wk periods, volunteers daily consumed 500 mL orange juice, 500 mL control drink plus hesperidin (CDH), or 500 mL control drink plus placebo (CDP). All measurements and blood collections were performed in overnight-fasted subjects before and after the 4-wk treatment periods. The postprandial study was conducted at the beginning of each experimental period.
RESULTS: Diastolic blood pressure (DBP) was significantly lower after 4 wk consumption of orange juice or CDH than after consumption of CDP (P = 0.02), whereas microvascular endothelium-related reactivity was not significantly affected when measured after an overnight fast. However, both orange juice and CDH ingestion significantly improved postprandial microvascular endothelial reactivity compared with CDP (P < 0.05) when measured at the peak of plasma hesperetin concentration.
CONCLUSIONS: In healthy, middle-aged, moderately overweight men, orange juice decreases DBP when regularly consumed and postprandially increases endothelium-dependent microvascular reactivity. Our study suggests that hesperidin could be causally linked to the beneficial effect of orange juice. This trial is registered at as NCT00983086.
Christine Morand; Claude Dubray; Dragan Milenkovic; Delphine Lioger; Jean François Martin; Augustin Scalbert; Andrzej Mazur
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-11-10
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  93     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  AIM; IM    
INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France.
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MeSH Terms
Antioxidants / metabolism
C-Reactive Protein / analysis
Citrus sinensis*
Cross-Over Studies
Diastole / drug effects*
Endothelium, Vascular / drug effects*,  physiology
Hesperidin / pharmacology*
Middle Aged
Oxidative Stress
Vasodilation / drug effects
Reg. No./Substance:
0/Antioxidants; 520-26-3/Hesperidin; 9007-41-4/C-Reactive Protein

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